Results 51 to 60 of about 339,440 (296)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry [PDF]

, 2013
Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications.
Alexander, Morgan R., Anderson, Daniel G., Davies, Martyn C., Hook, Andrew L., Langer, Robert, Scurr, David J., Williams, Paul   +6 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging

Journal of Lipid Research, 2008
Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi3+ liquid metal ion gun under static ...
Nora Tahallah, Alain Brunelle, Sabine De La Porte, Olivier Laprévote   +3 more
doaj   +1 more source

Linking biogenic hydrocarbons to biogenic aerosol in the Borneo rainforest [PDF]

Atmospheric Chemistry and Physics, 2013
Emissions of biogenic volatile organic compounds are though to contribute significantly to secondary organic aerosol formation in the tropics, but understanding these transformation processes has proved difficult, due to the complexity of the chemistry ...
J. F. Hamilton, M. R. Alfarra, N. Robinson, M. W. Ward, A. C. Lewis, G. B. McFiggans, H. Coe, J. D. Allan   +7 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Biological tissue sample preparation for time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging

Nano Convergence, 2018
Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical technique rapidly expanding in use in biological studies. This technique is based on high spatial resolution (50–100 nm), high surface sensitivity (1–2 nm top-layer), and ...
Sohee Yoon, Tae Geol Lee
doaj   +1 more source

An origin behind Rashba spin splitting within inverted doped sGe heterostructures [PDF]

, 2017
In this paper, we demonstrate why cubic Rashba spin splitting is observed within inverted doped strained germanium (sGe) hetrostructures. Magnetotransport measurements showed beating within the SdH oscillation, with fast Fourier analysis revealing ...
Dobbie, A., Gabani, S., Hassan, A. H. A., Leadley, D. R. (David R.), Mironov, O A., Morris, R. J. H. (Richard J. H.)   +5 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Nano-Scale Secondary Ion Mass Spectrometry: A Paradigm Shift in Soil Science

Journal of Spectroscopy
Soils exhibit structural heterogeneity across diverse spatio-temporal scales, yielding myriad of microhabitats, highlighting the need for a nuanced understanding of the intricate interactions within the soil matrix.
Yasir Hanif Mir, Anzhen Qin, Shakeel Mir, Shafeeq Ur Rahman, Mehnaza Mushtaq, Mumtaz A. Ganie, M. H. Chesti, Javid A. Bhat, Zahoor A. Baba, M. Auyoub Bhat, Inayat M. Khan, Rehana Rasool, Aanisa Manzoor Shah, Shazia Sadiq, Syed Mohammed Basheeruddin Asdaq, Mohammad Javed Ansari, Ghulam Yasin   +16 more
doaj   +1 more source