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Elucidating the functional anatomy of secondary lymphoid organs
Current Opinion in Immunology, 2004Functional anatomy offers an attempt to exploit anatomical information as a platform from which to decipher mechanistic details of complex or multistep immunological processes. Immune function depends on structural organization, therefore this approach contributes to a comprehensive understanding of the immune system.
Oliver, Pabst +3 more
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Phosphatidylserine Lipid Nanoparticles Promote Systemic RNA Delivery to Secondary Lymphoid Organs
Nano Letters, 2022Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current delivery method relies on the drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections, an efficient mRNA delivery carrier for SLOs-targeting delivery by systemic administration (IV) is highly ...
Sijin Luozhong +9 more
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Antigen trapping in Ambystoma mexicanum role of secondary lymphoid organs
Developmental & Comparative Immunology, 1981Abstract The fate of radiolabelled polyvinylpyrrolidone (PVP), injected into neotenous adult Ambystoma mexicanum , showed antigen trapping exclusively by the spleen; low temperatures did not inhibit such trapping. Injection of horse erythrocytes (HRBCs) resulted in the apperance of specific rosette-forming cells (RFCs) in the spleen, liver and ...
A M, Tahan, R D, Jurd
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Functional Organization of Secondary Lymphoid Organs by the Chemokine System
2000The development of an adaptive immune response requires well coordinated mechanisms in order to navigate circulating immune cells through peripheral tissues and into secondary lymphoid organs. There is strong experimental evidence that chemokines and their receptors are responsible for recruiting cells involved in inflammatory processes as well as for ...
M, Lipp +6 more
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MAIDS resistance-associated gene expression patterns in secondary lymphoid organs
Immunogenetics, 2008Murine acquired immunodeficiency syndrome (MAIDS) is caused by exposure to murine leukemia virus and serves as a model to study human AIDS. In MAIDS-susceptible C57BL/6 mice, virus exposure leads to progressive immune deficiency, while resistant strains such as BALB/c recover from infection and develop protective immunity. The goal of this study was to
Suprawee, Tepsuporn +3 more
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Chemokines and Cell Migration in Secondary Lymphoid Organs
Science, 1999As few as one in 100,000 B and T lymphocytes are specific for a single protein antigen, such as tetanus toxin, yet these cells must come together if an antibody response is to occur. Bringing antigen-presenting cells and rare antigen-specific B and T lymphocytes into physical contact is a principal function of secondary lymphoid organs. In the last few
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Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature
2013Although the initial event in lymphatic endothelial specification occurs slightly before the initiation of lymph node formation in mice, the development of lymphatic vessels and lymph nodes occurs within the same embryonic time frame. Specification of lymphatic endothelial cells starts around embryonic day 10 (E10), followed by endothelial cell budding
van de Pavert, S.A., Mebius, R.E.
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Tissue Engineering the Thymus and Secondary Lymphoid Organs
Postdoc Journal, 2013Tissue engineering is making great strides to repair disease and damage in a wide range of tissues, many of which are high profile and well documented. However, the thymus and secondary lymphoid organs are tissues which have not received significant attention from the research community but are nonetheless important targets for tissue engineering based
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CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS
Annual Review of Immunology, 2005▪ Abstract Secondary lymphoid organs serve as hubs for the adaptive immune system, bringing together antigen, antigen-presenting cells, and lymphocytes. Two families of G protein–coupled receptors play essential roles in lymphocyte migration through these organs: chemokine receptors and sphingosine-1-phosphate (S1P) receptors.
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CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ
International Reviews of Immunology, 2018Neema Negi, B. Das
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