Results 81 to 90 of about 182,231 (346)

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

Chicken Secondary Lymphoid Tissues—Structure and Relevance in Immunological Research

Animals
Recent discoveries have indicated the importance of developing modern strategies for vaccinations, more ethical research models, and effective alternatives to antibiotic treatment in farm animals.
Cassandra Ceccopieri, Jan P. Madej
doaj   +1 more source

Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis

Cells, 2021
Immunotherapies provide a potential treatment option for currently incurable bone metastases. Bone marrow is an important secondary lymphoid organ with a unique immune contexture.
Tiina E. Kähkönen, Jussi M. Halleen, Jenni Bernoulli   +2 more
doaj   +1 more source

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]

, 2016
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
A Egle, A Enders, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Villunger, AE Weant, AR Delbridge, BA Croker, Cassandra J Vandenberg, DA Hildeman, DA Steimer, E Lagasse, E Schneider, EA Reap, EM Carrington, F Rieux-Laucat, GH Fisher, I Dzhagalov St, I Vikstrom, IN Lavrik, J Hutcheson, J Opferman, JI Fletcher, JJ Weening, JM Brouwer, JT Opferman, K Fecho, K Iwai, K Nakayama, KA Fortner, KD Mason, Kirsteen J Campbell, KJ Campbell, KL O'Neill, L Chen, Lorraine A O’Reilly, M Pellegrini, MN Martina, Natasha S Anstee, P Bouillet, P Hughes, PD Hughes, PE Czabotar, PE Czabotar, Peter D Hughes, PH Krammer, PL Cohen, R Watanabe-Fukunaga, RM Perciavalle, S Cory, S Ogilvy, SF Fischer, SN Willis, SN Willis, Suzanne Cory, T Kuwana, T Moldoveanu, TH Price, TJ McDonnell, V Peperzak, WC Liles, WF Davidson   +65 more
core   +3 more sources

Transfer of Central Nervous System Autoantigens and Presentation in Secondary Lymphoid Organs [PDF]

The Journal of Immunology, 2002
AbstractDendritic cells are thought to regulate tolerance induction vs immunization by transferring Ags and peripheral signals to draining lymph nodes (LN). However, whether myelin Ag transfer and presentation in LN occurs during demyelinating brain disease is unknown.
de Vos, Alex F., van Meurs, Marjan, Brok, Herbert P., Boven, Leonie A., Hintzen, Rogier Q., van der Valk, Paul, Ravid, Rivka, Rensing, Susanne, Boon, Louis, Hart, Bert A. ’t, Laman, Jon D.   +10 more
openaire   +4 more sources

CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs

Scientific Reports, 2016
Stromal cells in secondary lymphoid organs (SLOs) are non-hematopoietic cells involved in the regulation of adaptive immune responses. Three major stromal populations have been identified in adult SLOs: fibroblastic reticular cells (FRCs), follicular ...
A. Prados, G. Kollias, V. Koliaraki
semanticscholar   +1 more source

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

Cell Research, 2020
The multifaceted organization of the immune system involves not only patrolling lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs but also immune cells that establish permanent tissue-residency.
Christoph S. N. Klose, D. Artis
semanticscholar   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes. [PDF]

, 1989
Lymphocyte migration from the blood into most secondary lymphoid organs is initiated by a highly selective adhesive interaction with the endothelium of specialized blood vessels known as high endothelial venules (HEV).
Geoffroy, JS, Rosen, SD
core  

Cadaveric small bowel and small bowel-liver transplantation in humans [PDF]

, 1992
Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults.
Abu-Elmagd, K, Casavilla, A, Demetris, AJ, Fung, JJ, Iwaki, Y, Jain, A, Murase, N, Nakamura, K, Reyes, J, Starzl, TE, Thiel, DV, Todo, S, Tzakis, AG, Yagihashi, A   +13 more
core   +1 more source