Results 41 to 50 of about 5,031,265 (399)

Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates

Msphere, 2020
Much of what we know about the genetics underlying secondary metabolite (SM) production and the function of SMs in the model fungus Aspergillus nidulans comes from a single reference genome.
Milton T. Drott, R. W. Bastos, A. Rokas, L. Ries, T. Gabaldón, G. Goldman, N. Keller, C. Greco   +7 more
semanticscholar   +1 more source

Elicitation of secondary metabolism in actinomycetes

Biotechnology Advances, 2015
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions.
Ronald J. Quinn, Mohamed Kamel, Tanja Grkovic, Ute Hentschel, Usama Ramadan Abdelmohsen, Usama Ramadan Abdelmohsen, Srikkanth Balasubramanian   +6 more
openaire   +5 more sources

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +9 more sources

MoLAEA Regulates Secondary Metabolism in Magnaporthe oryzae

Msphere, 2020
M. oryzae causes blast disease, the most serious disease of cultivated rice affecting global rice production. The genome of M. oryzae has been shown to have a number of genes involved in secondary metabolism, but most of them are uncharacterized. In fact,
P. Saha, Suvranil Ghosh, Subhankar Roy-Barman   +2 more
semanticscholar   +1 more source

Impairment of NADH dehydrogenase and regulation of anaerobic metabolism by the small RNA RyhB and NadE for improved biohydrogen production in Enterobacter aerogenes

Biotechnology for Biofuels, 2017
Background Enterobacter aerogenes is a facultative anaerobe and is one of the most widely studied bacterial strains because of its ability to use a variety of substrates, to produce hydrogen at a high rate, and its high growth rate during dark ...
Yan Wu, Yaqiao Hao, Xuan Wei, Qi Shen, Xuanwei Ding, Liyan Wang, Hongxin Zhao, Yuan Lu   +7 more
doaj   +1 more source

Comprehensive chemical profiling of two Dendrobium species and identification of anti-hepatoma active constituents from Dendrobium chrysotoxum by network pharmacology

BMC Complementary Medicine and Therapies, 2023
Background Dendrobium nobile and Dendrobium chrysotoxum are important species of the genus Dendrobium and have great economic and medicinal value. However, the medicinal properties of these two plants remain poorly understood.
Xia Jie, Yin Feng, Fang Jiahao, Lou Ganggui, Yu Jiani, Xu Zhongyu, Yuan Yuan, Zhang Tinggang, Zhang Xiaodan, Liang Zongsuo   +9 more
doaj   +1 more source

Differential Expression of Genes Related to Growth and Aflatoxin Synthesis in Aspergillus flavus When Inhibited by Bacillus velezensis Strain B2

Foods, 2022
Aspergillus flavus is a saprophytic soil fungus that infects and contaminates seed crops with the highly carcinogenic aflatoxin, which brings health hazards to animals and humans.
Qiaoyun Wu, Huanhuan Li, Sunxing Wang, Zhongnian Zhang, Zhipeng Zhang, Tuwei Jin, Xiufang Hu, Guohong Zeng   +7 more
doaj   +1 more source

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy [PDF]

, 2017
Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of ...
Asadollahi, Ebrahim, Baes, Myriam, Blanz, Judith, Brügger, Britta, de Hoz, Livia, Kassmann, Celia Michèle, Kleinecke, Sandra, Kungl, Theresa, Lüchtenborg, Christian, McGonigal, Rhona, Möbius, Wiebke, Naseri, Kobra, Nave, Klaus-Armin, Quintes, Susanne, Richert, Sarah, Sachsenheimer, Timo, Sereda, Michael W., Willison, Hugh   +17 more
core   +3 more sources

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

The Plant Short-Chain Dehydrogenase (SDR) superfamily:genome-wide inventory and diversification patterns [PDF]

, 2012
Background Short-chain dehydrogenases/reductases (SDRs) form one of the largest and oldest NAD(P)(H) dependent oxidoreductase families. Despite a conserved 'Rossmann-fold' structure, members of the SDR superfamily exhibit low sequence similarities, which
Kallberg, Yvonne, Moummou, Hanane, Persson, Bengt, Tonfack, Libert Brice, Van der Rest, Benoît   +4 more
core   +4 more sources