Results 51 to 60 of about 4,360,894 (311)

The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J., Stanley-Wall, Nicola R.; id_orcid, Coulthurst, Sarah J.; id_orcid   +2 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Functional characterization of HMG_9 and C2H2.07 as positive regulators of ganoderic acid biosynthesis in Ganoderma lucidum

Microbial Cell Factories
Background Ganoderic acids (GAs) are high-value lanostane-type triterpenoids produced by Ganoderma lucidum (G. lucidum) and are responsible for its diverse pharmacological activities. Previous studies have elucidated key enzymatic steps of the mevalonate
Yihong Li, Miaoqing Li, Liwei Liu, Wan Yang, Jihong Yang, Wei Li, Rui Zhang, Zongqi Yang, Zongsuo Liang, Zhenhao Li, Dongfeng Yang   +10 more
doaj   +1 more source

Functional characterization of transcription factors GlZn2Cys6_82 regulating ganoderic acids in Ganoderma lucidum

Mycology
Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional regulation of GA biosynthesis remains
Yihong Li, Liwei Liu, Miaoqing Li, Wan Yang, Xiaofeng Feng, Lisa Mao, Haisheng Yang, Jinyu Hu, Shaohua Wu, Wei Li, Rui Zhang, Jihong Yang, Zongqi Yang, Zongsuo Liang, Zhenhao Li, Dongfeng Yang   +15 more
doaj   +1 more source

Genome Sequence Resource for Ilyonectria mors-panacis, Causing Rusty Root Rot of Panax notoginseng

Molecular Plant-Microbe Interactions, 2019
Ilyonectria mors-panacis is the cause of a serious disease hampering the production of Panax notoginseng, an important Chinese medicinal herb, widely used for its anti-inflammatory, antifatigue, hepato-protective, and coronary heart disease prevention ...
Bo Zhu, Sai Wang, Chun-Yi Mi, Rui-Huan Yang, Guo-Hong Zen, Xiu-Fang Hu   +5 more
doaj   +1 more source

Ultrastructural Alterations in Cells of Sunflower Linear Glandular Trichomes during Maturation

Plants, 2021
Sunflower and related taxa are known to possess a characteristic type of multicellular uniseriate trichome which produces sesquiterpenes and flavonoids of yet unknown function for this plant. Contrary to the metabolic profile, the cytological development
Evelyn Amrehn, Otmar Spring
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mr-lac3 and Mr-lcc2 in Metarhizium robertsii Regulate Conidiation and Maturation, Enhancing Tolerance to Abiotic Stresses and Pathogenicity

Journal of Fungi
As a type of multicopper oxidase, laccases play multiple biological roles in entomopathogenic fungi, enhancing their survival, development, and pathogenicity. However, the mechanisms by which laccases operate in these fungi remain under-researched.
Qiaoyun Wu, Yingying Ye, Yiran Liu, Yufan He, Xing Li, Siqi Yang, Tongtong Xu, Xiufang Hu, Guohong Zeng   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structure and biosynthesis of fungal secondary metabolites [PDF]

, 2013
The root rot pathogen Heterobasidion annosum s.l., i.e. H. abietinum, H. parviporum, H. annosum s.s., H. irregulare and H. occidentale, and the biocontrol fungus Phlebiopsis gigantea were investigated regarding their secondary metabolites.
Hansson, David
core   +1 more source