Results 51 to 60 of about 836,378 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The complete chloroplast genome of Russian sage Salvia yangii B. T. Drew (Lamiaceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome of Russian sage Salvia yangii B. T. Drew was assembled in this study. The genome is 151,473 bp in length and contained 129 encoded genes in total, including 84 protein-coding genes, eight ribosomal RNA genes, and 37 ...
Meng-Ting Cao, Jun-Jie Wu, Rui-Hong Wang, Ling Xu, Zhe-Chen Qi, Yu-Kun Wei   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Functional characterization of HMG_9 and C2H2.07 as positive regulators of ganoderic acid biosynthesis in Ganoderma lucidum

Microbial Cell Factories
Background Ganoderic acids (GAs) are high-value lanostane-type triterpenoids produced by Ganoderma lucidum (G. lucidum) and are responsible for its diverse pharmacological activities. Previous studies have elucidated key enzymatic steps of the mevalonate
Yihong Li, Miaoqing Li, Liwei Liu, Wan Yang, Jihong Yang, Wei Li, Rui Zhang, Zongqi Yang, Zongsuo Liang, Zhenhao Li, Dongfeng Yang   +10 more
doaj   +1 more source

Functional characterization of transcription factors GlZn2Cys6_82 regulating ganoderic acids in Ganoderma lucidum

Mycology
Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional regulation of GA biosynthesis remains
Yihong Li, Liwei Liu, Miaoqing Li, Wan Yang, Xiaofeng Feng, Lisa Mao, Haisheng Yang, Jinyu Hu, Shaohua Wu, Wei Li, Rui Zhang, Jihong Yang, Zongqi Yang, Zongsuo Liang, Zhenhao Li, Dongfeng Yang   +15 more
doaj   +1 more source

Genome Sequence Resource for Ilyonectria mors-panacis, Causing Rusty Root Rot of Panax notoginseng

Molecular Plant-Microbe Interactions, 2019
Ilyonectria mors-panacis is the cause of a serious disease hampering the production of Panax notoginseng, an important Chinese medicinal herb, widely used for its anti-inflammatory, antifatigue, hepato-protective, and coronary heart disease prevention ...
Bo Zhu, Sai Wang, Chun-Yi Mi, Rui-Huan Yang, Guo-Hong Zen, Xiu-Fang Hu   +5 more
doaj   +1 more source

Disorders of Human Coenzyme Q10 Metabolism: An Overview

, 2020
Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant, plays an important role in ...
Iain Hargreaves, Robert A. Heaton, David Mantle   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mr-lac3 and Mr-lcc2 in Metarhizium robertsii Regulate Conidiation and Maturation, Enhancing Tolerance to Abiotic Stresses and Pathogenicity

Journal of Fungi
As a type of multicopper oxidase, laccases play multiple biological roles in entomopathogenic fungi, enhancing their survival, development, and pathogenicity. However, the mechanisms by which laccases operate in these fungi remain under-researched.
Qiaoyun Wu, Yingying Ye, Yiran Liu, Yufan He, Xing Li, Siqi Yang, Tongtong Xu, Xiufang Hu, Guohong Zeng   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source