Results 61 to 70 of about 4,360,894 (311)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Abiotic stress-induced changes in Tetrastigma hemsleyanum: insights from secondary metabolite biosynthesis and enhancement of plant defense mechanisms

BMC Plant Biology
Tetrastigma hemsleyanum, a traditional Chinese medicinal plant with anti-inflammatory, anti-cancer, and anti-tumor properties, faces increasing abiotic stress due to climate change, agricultural chemicals, and industrialization.
Minmin Chen, Xiaoqun Wang, Xiawen Zhou, Baiyu Huang, Yujie Zhao, Haiying Liu, Qiuling He   +6 more
doaj   +1 more source

Transcriptome profiling of a novel Enterobacter aerogenes mutant with mannose-rich exopolysaccharide phenotype induced by phosphoenolpyruvate carboxylase inactivation

Applied and Environmental Microbiology
Mannose, a common monosaccharide with primary functions in protein glycosylation and immune regulation, has been widely used in medicine, cosmetics, and food additives, increasing its economic value.
Xinru Peng, Jiale Chen, Yilin Ding, Ruoxuan Bai, Ping Lu, Fangxu Xu, Guohong Zeng, Hongxin Zhao   +7 more
doaj   +1 more source

The complete chloroplast genome sequence of Japanese buttercup Ranunculus japonicus Thunb.

Mitochondrial DNA. Part B. Resources, 2021
Ranunculus japonicus is an important medicinal herb widely used in East Asia. In this study, we report the first complete chloroplast genome sequence of Ranunculus japonicus using next-generation sequencing technology.
Wen-Qiong Zeng, Hua-Jian Yan, Yun-Zhe Wu, Rui-rui Wang, Xian-Fei Xiao, Zhe-Chen Qi, Xiao-Ling Yan   +6 more
doaj   +1 more source

Elicitation of secondary metabolism in actinomycetes

Biotechnology Advances, 2015
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions.
Abdelmohsen, Usama Ramadan, Grkovic, Tanja, Balasubramanian, Srikkanth, Kamel, Mohamed Salah, Quinn, Ronald J, Hentschel, Ute   +5 more
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Integration of metabolomics and proteomics reveals the mechanisms of seasonal accumulation and key regulatory networks of polysaccharides in Polygonatum odoratum

BMC Plant Biology
Background Polysaccharides are the primary active components responsible for the immunomodulatory and other pharmacological effects of Polygonatum odoratum.
Yifan Zhu, Shuang Liang, Dannuo Fu, Hongwei Fu, Hongxin Zhao   +4 more
doaj   +1 more source

Secondary and Tertiary Prevention of Inborn Errors of Metabolism

, 2020
This thesis is focused on understanding inborn errors of metabolism, secondary and tertiary prevention of them, and also a feature addressing the limitations to effective management in developing world countries.
Olaosebikan, Kikelomo Olamide
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source