Results 71 to 80 of about 5,031,265 (399)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour [PDF]

, 2020
We report the case of a 79-year-old male with previous history of non-Hodgkin's lymphoma in remission, who presented acutely to the Accident and Emergency department with recurrent episodes of hypoglycaemia.
Dimitriadis, Georgios K., Drakou, Eftychia E., Ganguly, Ratnadeep, Giovos, Georgios, Grossman, Ashley B., Kosmas, Christos, Leca, Bianca, Murthy, Narasimha, Onyema, Michael C., Randeva, Harpal S.   +9 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Chloroplast genome characteristics and phylogenetic analysis of Macropanax rosthornii (Harms) C.Y. Wu ex G. Hoo (Araliaceae)

Mitochondrial DNA. Part B. Resources
Macropanax rosthornii (Harms) C.Y.Wu ex G.Hoo 1900 is a small tree or evergreen shrub of the family Araliaceae, mainly distributed in southern China and Vietnam with a small distribution area. M. rosthornii is a kind of high-quality wild ornamental plant
Shuxin Du, Huiying Huang, Shuhui Yang, Tianyi Gu, Mengli Zhou, Ruihong Wang   +5 more
doaj   +1 more source

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism.

Natural product reports (Print), 2018
Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-containing monooxygenases that perform diverse catalytic roles in many species, including bacteria. The P450 superfamily is widely known for the hydroxylation of unactivated
Anja Greule, Jeanette E. Stok, J. D. De Voss, M. Cryle   +3 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Abiotic stress-induced changes in Tetrastigma hemsleyanum: insights from secondary metabolite biosynthesis and enhancement of plant defense mechanisms

BMC Plant Biology
Tetrastigma hemsleyanum, a traditional Chinese medicinal plant with anti-inflammatory, anti-cancer, and anti-tumor properties, faces increasing abiotic stress due to climate change, agricultural chemicals, and industrialization.
Minmin Chen, Xiaoqun Wang, Xiawen Zhou, Baiyu Huang, Yujie Zhao, Haiying Liu, Qiuling He   +6 more
doaj   +1 more source

Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces [PDF]

, 2010
Limitation of different nutrients in Streptomyces coelicolor A3(2) triggers nutrient‐stress responses, mediated by PhoP, GlnR, AfsR and other regulators, that are integrated at the molecular level and control secondary metabolite biosynthesis and ...
Apel, Borodina, Brzoska, Champness, Chang, Choi, Colson, Commichau, Díaz, Esteban, Fink, Fisher, Floriano, Ghorbel, Ghorbel, Hesketh, Hobbs, Hoi, Horinouchi, Iwasaki, Kasahara, Kezuka, Krol, Larson, Lee, Lu, Makarewicz, Martín, Martín, Martín, Masayama, Matsumoto, Mendes, Merrick, Moura, Nieselt, Nilsson, Nothaft, Oh, Overduin, Parker, Price, Puri-Taneja, Quiquampoix, Rao, Reuther, Rigali, Rodríguez-García, Rodríguez-García, Saito, Santos-Beneit, Santos-Beneit, Santos-Beneit, Scheu, Schrempf, Shu, Sola-Landa, Sola-Landa, Sola-Landa, Sonenshein, Tiffert, Titball, Torriani, Uesugi, VanBogelen, Vögtli, Wang, Wanner, Wray, Wray   +69 more
core   +1 more source

The Regulation of Plant Secondary Metabolism in Response to Abiotic Stress: Interactions Between Heat Shock and Elevated CO2

Frontiers in Plant Science, 2019
Future climate change is set to have an impact on the physiological performance of global vegetation. Increasing temperature and atmospheric CO2 concentration will affect plant growth, net primary productivity, photosynthetic capability, and other ...
Nichola Austen, Heather J. Walker, J. A. Lake, G. Phoenix, D. Cameron   +4 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source