Results 91 to 100 of about 375,474 (296)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Production of Fully Homozygous Genotypes from Various Edible Alliums

International Journal of Secondary Metabolite, 2016
Allium is a very large genus containing over 700 distinct species including the various edible onions, garlics, chives, and leeks. About a dozen of the species are economically important as crops or garden vegetables where as many others are cultivated ...
A. R. ALAN, A. KASKA, F. ÇELEBİ TOPRAK   +2 more
doaj  

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

The Influence of Licorice Root (Glycyrrhiza glabra) on Sex Reversal in Guppy Poecilia reticulata

International Journal of Secondary Metabolite, 2017
The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice is commonly present in menopausal botanical supplements in the United States.
Funda Turan
doaj   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Functional cartography of complex metabolic networks

, 2005
High-throughput techniques are leading to an explosive growth in the size of biological databases and creating the opportunity to revolutionize our understanding of life and disease.
A Arenas, A Wagner, AE Krause, AW Rives, E Ravasz, F Radicchi, H Jeong, H Jeong, H Ma, J-DJ Han, JA Papin, KA Eriksen, LAN Amaral, LAN Amaral, LH Hartwell, Luís A. Nunes Amaral, M Girvan, M Kanehisa, MEJ Newman, MEJ Newman, P Holme, R Albert, R Guimerà, R Guimerà, Roger Guimerà, S Kirkpatrick, S Schuster, S Schuster, S Wasserman, V Hatzimanikatis   +29 more
core   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Protein contents and antioxidant properties of pleurotus ostreatus cultivated on tea and espresso wastes

International Journal of Secondary Metabolite, 2017
In this study, Pleurotus ostreatus was cultivated on tea (Camellia sinensis) and espresso wastes. Tea wastes were used in two forms; sterilized or non-sterilized.
Ayşenur Yılmaz, Sibel Yıldız, Ceyhun Kılıç, Zehra Can   +3 more
doaj  

Determination of the Health Services Vocational School Students’ Thoughts and Usage Habits about Herbal Treatment

International Journal of Secondary Metabolite, 2017
Usage of complementary-alternative medicine (CAM) is increasing in a rapid manner. Among CAM, herbal applications come in the foreground. This cross-sectional study was conducted by using ‘questionnaire application method’ on 342 students in Inonu ...
Gülsüm Yetiş, Turgay Kolaç, Perihan Gürbüz, Zehra Deniz Yakıncı   +3 more
doaj   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source