Results 21 to 30 of about 217,149 (260)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of Salt Stress on Seed Germination, Shoot and Root Length in Basil (Ocimum basilicum)

International Journal of Secondary Metabolite, 2017
Salinity is one of the most environmental problems in arid and semi-arid region. It is an abiotic stress factor which restricts crop production and affects development of plants. One of the these plants is basil (Ocimum basilicum).
Mahmut Çamlıca, Gülsüm Yaldız
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of selenium on structure of the essential oil isolated from Satureja hortensis L. (Lamiaceae) under the cadmium stress

International Journal of Secondary Metabolite
One of the heavy metals which cause severe environmental pollution and biochemical changes in plants is Cadmium (Cd) while Selenium (Se) acts as an important anti-stress agent in plants. In the present research, the glasshouse experiment was conducted to
Iraj Azizi, Mohammad Asadi
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Total phenolic content and antioxidant activity of extracts obtained from tobacco waste seeds, grown under organic production

International Journal of Secondary Metabolite
This study aimed to determine the total phenolic content of Oriental tobacco waste seeds, grown under organic production, and to evaluate their antioxidant activity by extraction with different solvents under different conditions.
Desislava Kirkova, Margarita Docheva, Maria Angelova Romova, Liliya Stoyanova   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Essential Oil Composition of Endemic Sideritis leptoclada O. Schwarz& P. H. Davis (Lamiaceae) from Turkey by Using Two-Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry (GCxGC-TOF/MS)

International Journal of Secondary Metabolite, 2017
Sideritis genus is present by 46 species in Turkey with high endemism rate (ca. 82%). The chemical composition of essential oil obtained from the aerial parts of endemic Sideritis leptoclada O. Schwarz & P. H. Davis was investigated.
Gürkan SEMİZ, Mustafa Zafer ÖZEL
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Extraction of antioxidative principles of Achillea biserrata M. Bieb. and chromatographic analyses

International Journal of Secondary Metabolite, 2015
In this study, hexane, chloroform and water extracts were prepared by making consecutive extraction of Achillea biserrata from the family Asteraceae.
Gönül SERDAR, Münevver SÖKMEN, Ezgi DEMİR, Atalay SÖKMEN, Ersan BEKTAŞ   +4 more
doaj   +1 more source