Results 61 to 70 of about 3,054,813 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Extraction of antioxidative principles of Achillea biserrata M. Bieb. and chromatographic analyses

International Journal of Secondary Metabolite, 2015
In this study, hexane, chloroform and water extracts were prepared by making consecutive extraction of Achillea biserrata from the family Asteraceae.
Gönül SERDAR, Münevver SÖKMEN, Ezgi DEMİR, Atalay SÖKMEN, Ersan BEKTAŞ   +4 more
doaj   +1 more source

Structure-Activity and Antioxidant Properties of Quercetin and Its Co2+ Chelate

, 2021
Quercetin and its metal complexes have anti-oxidation, antibacterial, anti-tumor, and kinds of enzymatic activities. Studies in recent years, these activities are very important for health and pharmaceutics. The purpose of this manuscript is to determine
Kiraz, A.O., Aslı ÖZTÜRK KİRAZ, Yalcin, F., Fatih YALÇIN   +3 more
core   +1 more source

Streptomyces: The biofactory of secondary metabolites

Frontiers in Microbiology, 2022
Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries ...
Khorshed Alam, Arpita Mazumder, Suranjana Sikdar, Yi-Ming Zhao, Jinfang Hao, Chaoyi Song, Yanyan Wang, Rajib Sarkar, Saiful Islam, Youming Zhang, Youming Zhang, Aiying Li   +11 more
openaire   +3 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

A Comparative Study on Antioxidant and Antibacterial Activities of Four Senecio Species From Turkey

International Journal of Secondary Metabolite, 2015
The present study was conducted to investigate total phenolic content, antioxidant and antibacterial activity of four Senecio L. (Asteraceae). The in vitro antioxidant activities of extracts were evaluated with different antioxidant testing systems ...
Sevil ALBAYRAK, Ahmet AKSOY, Lutfiye YURTSEVEN, Abit YAŞAR   +3 more
doaj   +1 more source

Essential oil composition of two endemic Nepeta L. (Lamiaceae) taxa from Southwestern Turkey

, 2022
Nepeta L. is one of the important genus in the Lamiaceae family. It includes ca. 300 herbaceous species and mostly grows in Eurasia. Nepeta is represented in Turkey by 40 taxa and of these 16 are endemic.
Gürkan SEMİZ, Armağan, Metin, Metin ARMAĞAN, Batıkan GÜNAL, Günal, Batıkan, Semiz, Gürkan   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

International Journal of Secondary Metabolite, 2014
Carbon tetrachloride (CCl4) is a known hepatotoxic compound working through the generation of reactive free radicals. Selenium (Se) is an essential trace element required by animals and humans for protection against xenobiotic compounds.
L. B. ZAVODNIK, D. B. VOLOSHIN, A. SKOMOROSHKO, T. N. BUDKO1, V. I. KONDAKOV, R. N. LIAKH1, A. M. KHOKHA, B. PALECZ   +7 more
doaj  

Antibacterial and Antioxidant Activity of Isoflavans from the Roots of Rhynchosia ferruginea and In Silico Study on DNA Gyrase and Human Peroxiredoxin

, 2021
Rhynchosia ferruginea (Udusalim, Afan Oromo) is a medicinal plant traditionally used to treat skin infection, intestinal problems and amoebiasis. Silica gel chromatographic separation of dichloromethane/methanol (1:1) roots extract yielded isoflavan (1),
Hussien, Kalid, Eswaramoorthy, Rajalakshmanan, Annisa, Milkyas Endale, Kalid HUSSEİN, Yadessa MELAKU, Milkyas ENDALE ANNİSA, Melaku, Yadessa, Rajalakshmanan ESWARAMOORTHY   +7 more
core   +1 more source