Results 311 to 320 of about 3,826,489 (355)

Secondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
In ulcerative colitis, the loss of Odoribacter splanchnicus disrupts a microbiota‐metabolite‐neutrophil axis. Restoring this bacterium boosts lithocholic acid, which suppress neutrophil extracellular trap formation and eases colonic inflammation.
Jing Xu, Jianhong Li, Xue Guo, Chen Huang, Yao Peng, Haoming Xu, Yingfei Li, Jingkui Xu, Jinxia Hu, Yitong Liao, Yuqiang Nie, Youlian Zhou   +11 more
wiley   +1 more source

Overview of Primary and Secondary Metabolites of <i>Rugulopteryx okamurae</i> Seaweed: Assessing Bioactivity, Scalability, and Molecular Mechanisms. [PDF]

Mar Drugs
García-Cervantes AM, Prates JAM, Guil-Guerrero JL.   +2 more
europepmc   +1 more source

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Biological activity of secondary metabolites of actinomycetes and their potential sources as antineoplastic drugs: a review. [PDF]

Front Microbiol
Rui S, Fengrui G, Yining Z, Hong S, Xuewen Y, Changping W, Chunjia Y.   +6 more
europepmc   +1 more source

Selected Plant Essential and Seed Oils and their Secondary Metabolites Used as Insecticides: A Review

Banyaladzi Doctor Paphane, Dikabo Mogopodi, Bonang Nkoane, Nyasha Makuve   +3 more
openalex   +2 more sources

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Anti-Inflammatory Secondary Metabolites from <i>Penicillium</i> sp. NX-S-6. [PDF]

Mar Drugs
Peng H, Sun J, Zhang R, Qiu Y, Hong Y, Zhou F, Wang C, Hu Y, Wang X.   +8 more
europepmc   +1 more source

Walnut-tea intercropping model: Variations in secondary metabolites and microbial interactions in tea under metabolomics perspective

Houqiao Wang, Wenxia Yuan, Wei Huang, Qiaomei Wang, Tianyu Wu, Chun Wang, Weihao Liu, Shize Zhang, Baijuan Wang   +8 more
openalex   +1 more source

Nitrogen-containing secondary metabolites from Meliaceae Family and their biological activity: a review. [PDF]

Nat Prod Bioprospect
Martiningsih NW, Sinaga SE, Safriansyah W, Supratman U, Harneti D.   +4 more
europepmc   +1 more source