Results 311 to 320 of about 3,896,821 (401)

Chromosome-Scale Genome and Transcriptomic Analyses Reveal Differential Regulation of Terpenoid Secondary Metabolites in Hericium coralloides [PDF]

Kexin Meng, Junyi Lv, Tuo Zhang, Yuanyuan Liu, Peng Zhang, Yue Zhang, Banghui Hu, Qianhui Huang, Baogui Xie, Junsheng Fu   +9 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Differential accumulation of secondary metabolites as indicators of graft incompatibility in Cyclocarya paliurus. [PDF]

Sci Rep
Caowen S, Run X, Xuchen G, Xulan S, Shengzuo F.   +4 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Aluminum and copper oxide nanoparticles alter secondary metabolites, antioxidants, and biochemical markers in key lime: in vitro approach. [PDF]

BMC Plant Biol
El-Mahdy MT, Abulfadl EA, Dawood MFA.
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

The Potential of Plant Secondary Metabolites as Bread Mould Inhibitors: Exploring Their Individual and Combined Antifungal Effect. [PDF]

Foods
Lepoutre A, Debonne E, Van Genechten W, Martini S, Van Dijck P, Devlieghere F.   +5 more
europepmc   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Global trends in <i>Trichoderma</i> secondary metabolites in sustainable agricultural bioprotection. [PDF]

Front Microbiol
Cortez-Lázaro AA, Vázquez-Medina PJ, Caro-Degollar EM, García Evangelista JV, Cortez-Lázaro RA, Rojas-Paz JL, Legua-Cardenas JA, Fernandez-Herrera F, Pesantes-Rojas CR, Ocrospoma-Dueñas RW, Oliva-Cruz SM, Manes-Cangana GA, Romero Bozzetta JL, Leiva Espinoza ST.   +13 more
europepmc   +1 more source