Results 71 to 80 of about 3,896,821 (401)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Identification of Secondary Metabolites From Ethanol Extract of Ciplukan (Physalis Angulate) Leaves and Toxicity Test on Post-Larvae of Tiger Shrimp (Penaeus Monodon) [Identifikasi Senyawa Metabolit Sekunder Ektrak Etanol Daun Ciplukan (Physalis Angulata) Dan Uji Toksisitas Terhadap Sintasan Post Larva Udang Windu (Penaeus Monodon)] [PDF]

, 2019
Physalis angulata merupakan tumbuhan pekarangan yang telah banyak dimanfaatkan sebagai tumbuhan obat oleh masyarakat. Tumbuhan ini diduga memiliki metabolit sekunder yang dapat dimanfaatkan sebagai obat dan peningkatan nutrisi.
Awaludin, A. (Awaludin), Yulma, Y. (Yulma)   +1 more
core  

Euphorbia-derived natural products with potential for use in health maintenance [PDF]

, 2019
Euphorbia genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa
Adedoyin, Aleksandrov, Bard, Barla, Baslas, Chanda, Colley, Cui, Dabholkar, Deveci, Gaioni, Govaerts, Gupta, Hargreaves, Hassan, Jing, Kumara Swamy, Li, Lu, Ma, Mali, Mali, Merza, Mir, Ogbulie, Ogunlesi, Pascal, Polygenis-bigendako, Ram, Rehman, Shamsabadipour, Sharanappa, Suffness, Özbilgin, Özbilgin   +34 more
core   +4 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]

, 2001
This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Correlation Between Secondary Metabolites of Leaf and the Resistance to Leaf Rust (Hemileia vastatrix) on Several Arabica Coffee Clones

Ilmu Pertanian (Agricultural Science), 2019
Indicator of coffee resistance to leaf rust attack (Hemileia vastatrix) is needed to select superior coffee plants resistant to biotic stress. This study aims to find the relationship between the content of secondary metabolites and the intensity of leaf
Gatot Subroto, Dwi Erwin Kusbianto, Sholeh Avivi, Slameto Slameto, Setiyono Setiyono   +4 more
doaj   +1 more source

Phytotoxic metabolites produced by Botryosphaeriaceae involved in grapevine trunk diseases [PDF]

, 2013
Fungi belonging to the Botryosphaeriaceae family are well known as cosmopolitan pathogens, saprophytes and endophytes and occur on a wide range of hosts including grapevine.
Andolfi, Anna, Basso, Sara, Cimmino, Alessio, Deidda, Antonio, Evidente, Antonio, Linaldeddu, Benedetto Teodoro, Maddau, Lucia, Serra, Salvatorica   +7 more
core  

Plant Secondary Metabolites with an Overview of Populus

International Journal of Molecular Sciences, 2021
Populus trees meet continuous difficulties from the environment through their life cycle. To warrant their durability and generation, Populus trees exhibit various types of defenses, including the production of secondary metabolites.
A. Movahedi, Amir Almasi Zadeh Yaghuti, Hui Wei, P. Rutland, Weibo Sun, Mohaddeseh Mousavi, Dawei Li, Q. Zhuge   +7 more
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source