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Secondary Neurulation Defects: Retained Medullary Cord

Advances and Technical Standards in Neurosurgery, 2023
Retained medullary cord (RMC) is a defect resulting from impaired secondary neurulation. Intraoperatively, RMC is recognizable as an elongated cord-like structure caudal to the conus, that contains histologically confirmed neuroglial components and a lumen with an ependymal lining. It characteristically does not possess neurological function.
Kyung Hyun, Kim   +2 more
openaire   +4 more sources

MECHANISTIC INSIGHTS INTO SECONDARY NEURULATION

open access: yes, 2009
The central nervous system is formed by a series of movements referred to as neurulation. There are two modes of neurulation, known as primary and secondary neurulation. Primary neurulation occurs in anterior regions and involves an epithelial folding process.
Hong, Elim
core   +3 more sources

Disorders of Secondary Neurulation: Suggestion of a New Classification According to Pathoembryogenesis

Advances and Technical Standards in Neurosurgery, 2022
Recently, advanced knowledge on secondary neurulation and its application to the clinical experience have led to the deeper insight into the pathoembryogenesis of secondary neurulation with new classifications of the caudal spinal dysraphic entities.
Jeyul, Yang   +4 more
openaire   +4 more sources

Secondary Neurulation Defect: Terminal Myelocystocele, a Biological Leviathan

Advances and Technical Standards in Neurosurgery, 2023
Terminal myelocystocele (TMC) has been a puzzling entity of spinal dysraphism. It is found in the sacrococcygeal region usually forming a subcutaneous hump of various sizes. The wide variation of its morphology has been clarified by defining the essential and nonessential features as described in this chapter. Although it is not a common entity, TMC is
Ji Yeoun, Lee   +2 more
openaire   +4 more sources

Pathoembryogenesis of terminal myelocystocele: terminal balloon in secondary neurulation of the chick embryo

Child's Nervous System, 2013
Terminal myelocystocele (TMC) is thought to be caused by a misstep during secondary neurulation. However, due to the paucity of data on secondary neurulation and the rarity of TMC, proofs of this pathogenetic mechanism are unavailable. Based on a previous observation that TMC resembles a step of secondary neurulation in chick, a closer look was taken ...
Ji Yeoun, Lee   +8 more
openaire   +4 more sources

The distribution of cell surface glycoconjugates during mouse secondary neurulation

Anatomy and Embryology, 1989
During secondary neurulation in the mouse, the neural tube develops from the tail bud by caudal extension of the primary neurocoele. The mesenchymal cells of the tail bud become radially arranged around the neurocoele and undergo a mesenchymal to epithelial transformation to form a neuroepithelium.
C M, Griffith, M J, Wiley
openaire   +4 more sources

Effects of dexamethazone exposure on neural crest cells and primary and secondary neurulation during neurulation period in chick embryos

Turkish Neurosurgery, 2021
To evaluate the effects of dexamethasone (Dex) treatment on neural crest cells and primary and secondary neurulation in chick embryos.Sixty fertilized eggs with an average weight of 65 ± 2 g were incubated in 60%?70% humidity at 37.2°C ± 0.1°C. After 26 hours of incubation, the control group (n=12) received 0.1 mg/kg physiologic saline (S), group 1 (n ...
Serap Uslu   +5 more
openaire   +3 more sources

Glycoconjugates in normal and abnormal secondary neurulation

Teratology, 1995
AbstractIn chick embrayos, the anterior greater portion of the neural tube develops by the folding, apposition, and fusion of the neuroectoderm. The smaller caudal portion that forms the secondary neural tube (lumbosacral and coccygeal regions) is derived from the tail bud, an aggregate of mesenchymal cells located at the caudal limit of the body. Tail
C M, Griffith   +3 more
openaire   +2 more sources

Ultrastructure of secondary neurulation in the chick embryo

American Journal of Anatomy, 1980
AbstractFormation of the future lumbosacral level of the spinal cord was studied in two‐day‐old chick embryos by light and electron (transmission and scanning) microscopy. A neurulation overlap zone occupied this level. The dorsal portion of the neural tube formed by bending of the neural plate and approximation and fusion of neural folds (i.e., by ...
G C, Schoenwolf, J, Delongo
openaire   +2 more sources

Retinoic acid, midkine, and defects of secondary neurulation

Teratology, 2000
Retinoic acid (RA) is necessary for normal differentiation of the tail bud into the secondary neural tube. Excess RA, however, is teratogenic and causes neural tube defects (NTDs). The way in which RA modulates secondary neurulation is unclear but probably involves RA-regulated downstream genes such midkine (MK), which encodes a growth factor ...
M, Griffith, M H, Zile
openaire   +2 more sources

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