Results 81 to 90 of about 3,980,763 (249)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Country and Progressive National Party - Elector, vol. 6 (no. 9), November 15, 1932

, 1932
Country and Progressive National Party - Elector, vol. 6 (no.
Country and Progressive National Party
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Country and Progressive National Party - Campaign material for the 1929 Legislative Assembly elections

, 1929
Country and Progressive National Party - CCampaign material for the 1929 Legislative Assembly elections, Pamphlet no. 2, He can't get a job - change the government, Brisbane [with] Pamphlet no.
Country and Progressive National Party
core  

Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis

EBioMedicine, 2017
Background: Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete unusually ...
Krista Jones, Caroline Linhart, Clive Hawkins, Christopher Exley   +3 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Declaration of policy

, 1949
Declaration of Policy by the Progressive Conservative Party of NewfoundlandAdvancement of the national welfare -- Greater social security -- More work and wages through industrial development -- Progressive road policy -- Expansion of medical and health ...
Progressive Conservative Party of Canada. Newfoundland
core  

Folder 25: Notebook 1, 1976, 1978

, 1976
An official Progressive Voters League card for precinct 4465 with a list of candidates which the Progressive Voters League ...
Progressive Voters League
core   +1 more source

Siponimod in secondary progressive multiple sclerosis

International Archives of Health Sciences, 2020
Jamir Pitton Rissardo, Ana Leticia Fornari Caprara   +1 more
doaj   +1 more source