Results 51 to 60 of about 4,443,777 (293)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Effect of high hydrostatic pressure on the secondary structure of microbial transglutaminase

Czech Journal of Food Sciences, 2004
Enzyme activity and corresponding secondary structure, measured by circular dichroism was analysed before und after treatment of microbial transglutaminase at different temperatures (40, 80°C) and pressures (0.1, 200, 400, 600 MPa).
O. Menéndez, H. Rawel, U. Schwarzenbolz, T. Henle   +3 more
doaj   +1 more source

Nature of the glassy phase of RNA secondary structure

, 2002
We characterize the low temperature phase of a simple model for RNA secondary structures by determining the typical energy scale E(l) of excitations involving l bases. At zero temperature, we find a scaling law E(l) \sim l^\theta with \theta \approx 0.23,
Bundschuh R., Bundschuh R., Caracciolo S., F Krzakala, M Mézard, M Müller, M. Mézard, Marinari E., Orland H., Waterman M., Zuker M.   +10 more
core   +2 more sources

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Loquet, BI Giasson, BM Fung, C Wasmer, Chad M. Rienstra, CP Jaroniec, CR Bodner, CR Morcombe, D Eliezer, DS Wishart, DS Wishart, DS Wishart, E Oldfield, EA Greenbaum, Elisa Greggio, F Delaglio, G Comellas, G Comellas, G Comellas, G Cornilescu, Gemma Comellas, H Heise, H Heise, H van Melckebeke, J Li, JJ Zarranz, Julia M. George, K Iwata, K Takegoshi, KA Conway, KD Kloepper, L Narhi, Lars K. Rikardsen, LC Serpell, LR Lemkau, Luisel R. Lemkau, M Baldus, ME van Raaij, MG Spillantini, MH Polymeropoulos, MS Celej, N Ferguson, R Bussell, R Kruger, RA Fredenburg, S Hediger, Shin W. Lee, W Choi, Wendy S. Woods, WG Hoyer, Y Shen   +50 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Structural and Thermal Characterization of Protein Isolates from Australian Lupin Varieties as Affected by Processing Conditions

Foods, 2023
Proteins from the full and defatted flours of L. angustifolius cv Jurien and L. albus cv Murringo were prepared using alkaline extraction and iso-electric precipitation.
Lavaraj Devkota, Konstantina Kyriakopoulou, Robert Bergia, Sushil Dhital   +3 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Structural Analysis and Sensitization Prediction of the Allergic Proteins Ana o 2 and Ana o 3 in Cashew Nuts

Shipin gongye ke-ji, 2022
In order to definite the molecular structure and allergic characteristics of cashew nuts, the main allergic proteins were isolated and purified by organic solvent defatting, salting out, dialysis and Sephadex G-150 gel.
Ailin ZHANG, Huijuan ZHAO, Yue CHI, Xiaoyan LIANG, Xiaodan LI, Mei GUO   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source