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, 2013 Since its initial discovery, secretin is now coined as a classical hormone with widespread distribution. In particular, numerous studies have demonstrated the abundant expression of secretin and its receptor within various brain areas sparking interest of its potential as a brain peptide.
Cheng, CYY, Ng, SYL, Chow, BKC
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Secretin: A Pleiotrophic Hormone
Annals of the New York Academy of Sciences, 2006 Abstract: Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone. During the last century since its first discovery, the hormonal effects of secretin in the gastrointestinal tract were extensively studied, and its principal role in the periphery was found to ...
Chow, BKC, Chu, JYS, Yung, WH
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Gastroenterology, 1978
Several sensitive radioimmunoassay systems for secretin have been developed and reported1–6. The development of these assay systems depended upon the generation of a specific secretin antiserum and the iodination of secretin (natural porcine secretin, synthetic secretin or a tyrosyl derivative of secretin).
P L, Rayford +2 more
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Several sensitive radioimmunoassay systems for secretin have been developed and reported1–6. The development of these assay systems depended upon the generation of a specific secretin antiserum and the iodination of secretin (natural porcine secretin, synthetic secretin or a tyrosyl derivative of secretin).
P L, Rayford +2 more
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Molecular and Cellular Endocrinology, 2012 Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian ...
Yajun Wang, Frederick C Leung
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On the instability of secretin
Life Sciences, 1981Abstract Secretin has repeatedly been said to be unstable. We found that the biological potency of secretin solutions under some conditions decreased. We tested hypotheses about the cause(s). Adsorption of secretin on materials in which it is stored may account for most of the rapid decrease of biological potency.
H C, Beyerman +4 more
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Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin [PDF]
FEBS Letters, 1998 The secretin amino-terminal residues are essential for high affinity binding to its cognate receptor and for its biological activity. Mutation of the [Asp3] residue of secretin to [Asn3] decreased the ligand's affinity for the rat wild-type receptor 100 ...
Magali Waelbroeck +2 more
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Comprehensive Physiology, 1989
Abstract The sections in this article are: Discovery of Secretin Historical Background Isolation and Purification of Secretin ...
William Y. Chey, Ta‐Min Chang
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Abstract The sections in this article are: Discovery of Secretin Historical Background Isolation and Purification of Secretin ...
William Y. Chey, Ta‐Min Chang
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1958
Publisher Summary The mucosal lining of the alimentary tube forms a number of hormones which regulate the motor and secretory activities of the organs of digestion. The existence of five such hormones can be considered to be well established, which are: (1) gastrin, which stimulates gastric acid secretion, (2) cholecystokinin, which causes ...
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Publisher Summary The mucosal lining of the alimentary tube forms a number of hormones which regulate the motor and secretory activities of the organs of digestion. The existence of five such hormones can be considered to be well established, which are: (1) gastrin, which stimulates gastric acid secretion, (2) cholecystokinin, which causes ...
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Journal of Child and Adolescent Psychopharmacology, 1998
R, Perry, B S, Bangaru
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R, Perry, B S, Bangaru
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