Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Cell Research, 2015 Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers pyroptosis.
Wan-ting He +8 more
semanticscholar +1 more source
Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]
, 2001 Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K. +7 more
core +1 more source
EMBO Molecular Medicine, 2020 Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi +20 more
doaj +1 more source
Scientific Reports, 2017 Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life.
Tatiane Aparecida Ribeiro +19 more
doaj +1 more source
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]
, 2017 BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S +6 more
core +1 more source
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs
eLife, 2017 Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy +5 more
doaj +1 more source
Enterotoxigenic Escherichia coli induce pro-inflammatory responses in porcine intestinal epithelial cells [PDF]
, 2010 F4+ enterotoxigenic Escherichia coli (ETEC) cause severe diarrhoea in both neonatal and weaning piglets, resulting in morbidity and mortality. F4 fimbriae are a key virulence factor involved in the attachment of F4+ ETEC to the intestinal epithelium ...
Cox, Eric +4 more
core +1 more source
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.
Physiological Reviews, 2018 The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration.
P. Rorsman, F. Ashcroft
semanticscholar +1 more source
Does an Analysis of the Pulsatile Secretion Pattern of Adrenocorticotropin and Cortisol Predict the Result of Transsphenoidal Surgery in Cushing’s Disease. [PDF]
, 1993 The endocrinological, surgical, and histological findings of patients with ACTH-dependent Cushing's disease were correlated with the pulsatile secretion pattern of ACTH and cortisol and the outcome after transsphenoidal pituitary surgery.
Brabant, Georg +5 more
core +1 more source
Bacterial Secretion Systems: An Overview
Microbiology spectrum, 2016 Bacterial pathogens utilize a multitude of methods to invade mammalian hosts, damage tissue sites, and thwart the immune system from responding. One essential component of these strategies for many bacterial pathogens is the secretion of proteins across ...
Erin R Green, J. Mecsas
semanticscholar +1 more source