Results 21 to 30 of about 1,882,580 (346)

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean   +20 more
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Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2

Viruses, 2020
Glycoprotein G (gG) from herpes simplex virus type 1 and 2 (HSV-1 and HSV-2, respectively) functions as a viral chemokine binding protein (vCKBP). Soluble recombinant forms of gG of HSV-1 and HSV-2 (SgG1 and SgG2, respectively) enhance chemokine-mediated
Kai A. Kropp, Sangar Srivaratharajan, Birgit Ritter, Pengfei Yu, Simon Krooss, Felix Polten, Andreas Pich, Antonio Alcami, Abel Viejo-Borbolla   +8 more
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Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Scientific Reports, 2017
Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life.
Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Isabela Peixoto Martins, Audrei Pavanello, Júlio Cezar de Oliveira, Kelly Valério Prates, Rosiane Aparecida Miranda, Claudinéia Conationi da Silva Franco, Rodrigo Mello Gomes, Flávio Andrade Francisco, Vander Silva Alves, Douglas Lopes de Almeida, Veridiana Mota Moreira, Kesia Palma-Rigo, Elaine Vieira, Gabriel Sergio Fabricio, Marcos Ricardo da Silva Rodrigues, Wilson Rinaldi, Ananda Malta, Paulo Cezar de Freitas Mathias   +19 more
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Histology and histochemistry of the accessory gland of the female reproductive tract of Rhodnius neglectus Lent, 1954 (Hemiptera: Reduviidae) [PDF]

Brazilian Journal of Biology, 2023
Rhodnius neglectus is a wild triatomine, vector of the protozoan Trypanosoma cruzi, which causes Chagas’ disease, and feeds on the blood of small mammals, being essential for its growth and reproduction.
D. S. Gomes, C. J. F. Oliveira, T. M. C. Costa, A. Plata Rueda, J. C. Zanuncio, J. E. Serrão, E. A. Souza   +6 more
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Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

eLife, 2017
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen   +5 more
doaj   +1 more source

Bacterial Secretion Systems: An Overview

Microbiology spectrum, 2016
Bacterial pathogens utilize a multitude of methods to invade mammalian hosts, damage tissue sites, and thwart the immune system from responding. One essential component of these strategies for many bacterial pathogens is the secretion of proteins across ...
Erin R Green, J. Mecsas
semanticscholar   +1 more source

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

Frontiers in Physiology, 2018
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in secretory epithelial cells due to the defective ion flux across the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Tamara Madácsy, Tamara Madácsy, Petra Pallagi, Jozsef Maleth, Jozsef Maleth, Jozsef Maleth   +5 more
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Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion

Nature Cell Biology, 2009
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments. The pathways regulating this secretion are unknown.
F. Rodier, Jean-Philippe Coppé, C. Patil, W. Hoeijmakers, Denise P. Muñoz, Saba R. Raza, Adam Freund, E. Campeau, Albert R. Davalos, J. Campisi   +9 more
semanticscholar   +1 more source

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy

EMBO Molecular Medicine, 2020
Progressive myoclonus epilepsy (PME) of Unverricht–Lundborg type (EPM1) is an autosomal recessive neurodegenerative disorder with the highest incidence of PME worldwide.
Francesco Di Matteo, Fabrizia Pipicelli, Christina Kyrousi, Isabella Tovecci, Eduardo Penna, Marianna Crispino, Angela Chambery, Rosita Russo, Ane Cristina Ayo‐Martin, Martina Giordano, Anke Hoffmann, Emilio Ciusani, Laura Canafoglia, Magdalena Götz, Rossella Di Giaimo, Silvia Cappello   +15 more
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Efficient Autotransporter-Mediated Extracellular Secretion of a Heterologous Recombinant Protein by Escherichia coli

Microbiology Spectrum, 2023
The autotransporter protein secretion system has been used previously to target the secretion of heterologous proteins to the bacterial cell surface and the extracellular milieu at the laboratory scale.
Irene Beriotto, Christopher Icke, Yanina R. Sevastsyanovich, Amanda E. Rossiter, Giacomo Romagnoli, Silvana Savino, Freya J. Hodges, Jeffrey A. Cole, Allan Saul, Calman A. MacLennan, Adam F. Cunningham, Francesca Micoli, Ian R. Henderson   +12 more
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