Results 31 to 40 of about 1,596,415 (263)

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean   +20 more
doaj   +1 more source

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]

, 1992
To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin, Della Bruna, R., R. Della Bruna, Corvol, P., A. Kurtz, F. Pinet, P. Corvol, Pinet, F.   +7 more
core   +1 more source

Prediction of type III secretion signals in genomes of gram-negative bacteria [PDF]

, 2009
Background: Pathogenic bacteria infecting both animals as well as plants use various mechanisms to transport virulence factors across their cell membranes and channel these proteins into the infected host cell.
Löwer, Martin, Löwer Martin, Martin Löwer, Schneider, Gisbert (Prof. Dr.), Gisbert Schneider, Schneider Gisbert   +5 more
core   +2 more sources

Differentiation of Trafficking Pathways at Golgi Entry Core Compartments and Post-Golgi Subdomains

Frontiers in Plant Science, 2020
Eukaryotic cells have developed specialized membrane structures called organelles, which compartmentalize cellular functions and chemical reactions. Recent improvements in microscopy and membrane compartment isolation techniques are now sophisticating ...
Yoko Ito, Yohann Boutté
doaj   +1 more source

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Scientific Reports, 2017
Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life.
Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Isabela Peixoto Martins, Audrei Pavanello, Júlio Cezar de Oliveira, Kelly Valério Prates, Rosiane Aparecida Miranda, Claudinéia Conationi da Silva Franco, Rodrigo Mello Gomes, Flávio Andrade Francisco, Vander Silva Alves, Douglas Lopes de Almeida, Veridiana Mota Moreira, Kesia Palma-Rigo, Elaine Vieira, Gabriel Sergio Fabricio, Marcos Ricardo da Silva Rodrigues, Wilson Rinaldi, Ananda Malta, Paulo Cezar de Freitas Mathias   +19 more
doaj   +1 more source

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

eLife, 2017
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen   +5 more
doaj   +1 more source

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

Frontiers in Physiology, 2018
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in secretory epithelial cells due to the defective ion flux across the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Tamara Madácsy, Tamara Madácsy, Petra Pallagi, Jozsef Maleth, Jozsef Maleth, Jozsef Maleth   +5 more
doaj   +1 more source

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney [PDF]

, 1993
Using isolated rat kidneys perfused at controlled pressure, we examined a potential role of endothelium-derived relaxing factor (EDRF) in the pressure control of renin secretion.
Kurtz, Armin, Scholz, H., A Kurtz, Armin Kurtz, Holger Scholz, H Scholz   +5 more
core   +1 more source

Efficient Autotransporter-Mediated Extracellular Secretion of a Heterologous Recombinant Protein by Escherichia coli

Microbiology Spectrum, 2023
The autotransporter protein secretion system has been used previously to target the secretion of heterologous proteins to the bacterial cell surface and the extracellular milieu at the laboratory scale.
Irene Beriotto, Christopher Icke, Yanina R. Sevastsyanovich, Amanda E. Rossiter, Giacomo Romagnoli, Silvana Savino, Freya J. Hodges, Jeffrey A. Cole, Allan Saul, Calman A. MacLennan, Adam F. Cunningham, Francesca Micoli, Ian R. Henderson   +12 more
doaj   +1 more source

Environmental salinity determines the specificity and need for tat-dependent secretion of the YwbN protein in bacillus subtilis [PDF]

, 2011
Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into a mainstream pathway for protein secretion in certain
Miethke, Marcus, Theresa Winter, Schaffer Marc, van der Ploeg, René, Jan Maarten van Dijl, Harwood, Colin R., Denham, Emma, Monteferrante, Carmine G., Ulrike Mäder, Marcus Miethke, Maeder, Ulrike, van der Ploeg René, René van der Ploeg, Mohamed A Marahiel, Denham, Emma L., Harwood Colin R., Colin R. Harwood, van Dijl, Jan Maarten, Homuth, Georg, Hecker Michael, Monteferrante Carmine G., Carmine G Monteferrante, Georg Homuth, Mäder Ulrike, Mäder, Ulrike, van Dijl Jan Maarten, Winter Theresa, Emma L. Denham, Homuth Georg, Miethke Marcus, Schaffer, Marc, Michael Hecker, Marahiel Mohamed A., Hecker, Michael, Dijl, Jan Maarten van, Winter, Theresa, Haike Antelmann, Marahiel, Mohamed A., Antelmann, Haike, Antelmann Haike, Carmine G. Monteferrante, Emma L Denham, Denham Emma L., Colin R Harwood, Marc Schaffer, Mohamed A. Marahiel   +45 more
core   +2 more sources