Results 21 to 30 of about 2,059,241 (311)

Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition

Scientific Reports, 2017
Low intensity exercise during pregnancy and lactation may create a protective effect against the development of obesity in offspring exposed to overnutrition in early life.
Tatiane Aparecida Ribeiro, Laize Peron Tófolo, Isabela Peixoto Martins, Audrei Pavanello, Júlio Cezar de Oliveira, Kelly Valério Prates, Rosiane Aparecida Miranda, Claudinéia Conationi da Silva Franco, Rodrigo Mello Gomes, Flávio Andrade Francisco, Vander Silva Alves, Douglas Lopes de Almeida, Veridiana Mota Moreira, Kesia Palma-Rigo, Elaine Vieira, Gabriel Sergio Fabricio, Marcos Ricardo da Silva Rodrigues, Wilson Rinaldi, Ananda Malta, Paulo Cezar de Freitas Mathias   +19 more
doaj   +1 more source

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO Molecular Medicine, 2020
Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean   +20 more
doaj   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors [PDF]

, 2016
Autosomal dominant lateral temporal epilepsy (ADTLE) is a focal epilepsy syndrome caused by mutations in the LGI1 gene, which encodes a secreted protein.
Belluzzi, Elisa, Dazzo, Emanuela, Greggio, Elisa, Leonardi, Emanuela, Malacrida, Sandro, Nobile, Carlo, Tosatto, Silvio, Vitiello, Libero   +7 more
core   +3 more sources

Differentiation of Trafficking Pathways at Golgi Entry Core Compartments and Post-Golgi Subdomains

Frontiers in Plant Science, 2020
Eukaryotic cells have developed specialized membrane structures called organelles, which compartmentalize cellular functions and chemical reactions. Recent improvements in microscopy and membrane compartment isolation techniques are now sophisticating ...
Yoko Ito, Yohann Boutté
doaj   +1 more source

Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

eLife, 2017
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs.
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen   +5 more
doaj   +1 more source

Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. [PDF]

, 2013
BackgroundBrucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú.
Feldman, Kristyn E, Gilman, Robert H, Gotuzzo, Eduardo, Hoffmann, Alexander, Loriaux, Paul M, Saito, Mayuko, Siva, Tenaya, Tuero, Iskra, Villaverde, Homarh, Vinetz, Joseph M   +9 more
core   +3 more sources

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]

, 2017
BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S, Elkington, PT, Friedland, JS, Ong, CWM, Pabisiak, PJ, Roncaroli, F, Singh, P   +6 more
core   +1 more source

Enterotoxigenic Escherichia coli induce pro-inflammatory responses in porcine intestinal epithelial cells [PDF]

, 2010
F4+ enterotoxigenic Escherichia coli (ETEC) cause severe diarrhoea in both neonatal and weaning piglets, resulting in morbidity and mortality. F4 fimbriae are a key virulence factor involved in the attachment of F4+ ETEC to the intestinal epithelium ...
Cox, Eric, Devriendt, Bert, Goddeeris, Bruno, Stuyven, Edith, Verdonck, Frank   +4 more
core   +1 more source

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

Frontiers in Physiology, 2018
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in secretory epithelial cells due to the defective ion flux across the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Tamara Madácsy, Tamara Madácsy, Petra Pallagi, Jozsef Maleth, Jozsef Maleth, Jozsef Maleth   +5 more
doaj   +1 more source