Results 51 to 60 of about 546,603 (232)

Para-Bombay Phenotype of a Pregnant Mother in Malaysia: Transfusion for an Extremely Premature Baby

Oman Medical Journal, 2022
Para-Bombay blood phenotype is a rare blood group with limited cases reported worldwide. This blood group is characterized by the absence of ABH antigen on red blood cells but presence of ABH secretor substances in the body secretion. This rare phenotype
Tan Pei Pei, Nor Hafizah Ahmad, Noor Haslina Mohd Noor   +2 more
doaj   +1 more source

Correlation of a missense mutation in the human Secretor α1,2-fucosyltransferase gene with the Lewis(a+b+) phenotype: a potential molecular basis for the weak Secretor allele (Se w) [PDF]

Biochemical Journal, 1995
A missense mutation (A385 to T), predicting an Ile129 to Phe substitution, in the human Secretor alpha 1,2-fucosyltransferase gene was present in double dose in Lewis(a+b+) individuals, but not in Lewis(a-b+) individuals. Co-segregation of the Lewis(a+b+) phenotype with homozygosity for the mutation was also verified.
L C, Yu, Y H, Yang, R E, Broadberry, Y H, Chen, Y S, Chan, M, Lin   +5 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Host-Range shift between emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains: Host-range shift of P[8] rotaviruses

, 2020
International audienceIn Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype.
Le Pendu, Jacques, Imbert-Marcille, Berthe-Marie, Breiman, Adrien, Mastouri, Maha, Peltier, Cécile, Khachou, Amira, Le Moullac-Vaidye, Béatrice, Aouni, Mahjoub, Chouchane, Slaheddine, Ruvoën-Clouet, Nathalie   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Virus–Host Interactions Between Nonsecretors and Human NorovirusSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Human norovirus infection is the leading cause of acute gastroenteritis. Genetic polymorphisms, mediated by the FUT2 gene (secretor enzyme), define strain susceptibility.
Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Kara Jensen, Boyd L. Yount, Veronica Costantini, Matthew H. Collins, Caitlin E. Edwards, Timothy P. Sheahan, Jan Vinjé, Ralph S. Baric   +10 more
doaj   +1 more source

The Milk Metabolome of Non-secretor and Lewis Negative Mothers

Frontiers in Nutrition, 2021
Introduction: The functional role of milk for the developing neonate is an area of great interest, and a significant amount of research has been done. However, a lot of work remains to fully understand the complexities of milk, and the variations imposed
Aidong Wang, Aidong Wang, Petya Koleva, Petya Koleva, Elloise du Toit, Elloise du Toit, Donna T. Geddes, Donna T. Geddes, Daniel Munblit, Daniel Munblit, Daniel Munblit, Susan L. Prescott, Susan L. Prescott, Merete Eggesbø, Merete Eggesbø, Christine C. Johnson, Christine C. Johnson, Ganesa Wegienka, Ganesa Wegienka, Naoki Shimojo, Naoki Shimojo, Dianne Campbell, Dianne Campbell, Anita L. Kozyrskyj, Anita L. Kozyrskyj, Carolyn M. Slupsky, Carolyn M. Slupsky, Carolyn M. Slupsky   +27 more
doaj   +1 more source

α‐l‐FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood‐Group Phenotypes [PDF]

European Journal of Biochemistry, 1972
The presence of α‐l‐fucosyltransferases in human serum of different ABO, secretor and Lewis blood‐group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low‐molecular‐weight oligosaccharides, or a macromolecular glycoprotein, as acceptors.
H, Schenkel-Brunner, M A, Chester, W M, Watkins   +2 more
openaire   +2 more sources

Histo-blood group antigens and rotavirus vaccine virus shedding in Australian infants

, 2022
Rotavirus vaccine performance varies between high and low income countries. One possible explanation is inherited histo-blood group antigens (HBGAs) the expression of which differs between populations.
El-Heneidy, A, Whiley, DM, Lambert, SB, Sly, PD, Grimwood, K, Wang, CYT, Cheung, C, Ware, RS, Asmaa El-Heneidy, Robert S. Ware, Peter D. Sly, Stephen B. Lambert, David M. Whiley, Keith Grimwood, Catherine Cheung, Claire Y.T. Wang   +15 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source