Results 71 to 80 of about 546,603 (232)

Variant ABO Blood Group Alleles, Secretor Status, and Risk of Pancreatic Cancer: Results from the Pancreatic Cancer Cohort Consortium [PDF]

, 2010
BACKGROUND: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning.
Xiao-Ou Shu, Demetrius Albanes, Michaud, Dominique S., Geoffrey S. Tobias, Watters, Joanne, Mousheng Xu, Brian M. Wolpin, Julie B. Mendelsohn, Martin L. Olsson, Tobias, Geoffrey S, Emily Steplowski, Stolzenberg-Solomon, Rachael Z., Jacobs, Eric J., Jarmo Virtamo, Mendelsohn, Julie B, Peter Kraft, Bueno-de-Mesquita, H Bas, Susan E. Hankinson, Marie-Christine Boutron-Ruault, Gloria Petersen, Kevin B. Jacobs, Jacobs, Kevin B, Gaziano, J Michael, Allen, Naomi E, Bueno-de-Mesquita, H. Bas, J. Michael Gaziano, Yu, Kai, Steplowski, Emily, Jacobs, Eric J, Joanne Watters, Kraft, Peter, Patel, Alpa V., Julie E. Buring, Lund University., Hankinson, Susan E., Slimani, Nadia, Melissa A. Austin, Canzian, Federico, Austin, Melissa A., H. Bas Bueno-de-Mesquita, Kai Yu, Kala Visvanathan, Austin, Melissa A, Helzlsouer, Kathy, Anne Zeleniuch-Jacquotte, Sansbury, Leah, Federico Canzian, Edward L. Giovannucci, Robert N. Hoover, Buring, Julie E, Hallmans, Göran,, Buring, Julie E., Rachael Z. Stolzenberg-Solomon, Jean Wactawski-Wende, Laufey Amundadottir, Patricia Hartge, Allen, Naomi E., Boutron-Ruault, Marie-Christine, Michaud, Dominique S, Kooperberg, Charles, Charles Kooperberg, Göran Hallmans, Hankinson, Susan E, Chanock, Stephen J, Andrea LaCroix, Visvanathan, Kala, Alan A. Arslan, Petersen, Gloria, Charles S. Fuchs, Vineis, Paolo, Wactawski-Wende, Jean, Myron Gross, Hallmans, Göran, Amy Hutchinson, Gross, Myron, Maria-José Sanchéz, Chanock, Stephen J., Dimitrios Trichopoulos, Albanes, Demetrius, Zeleniuch-Jacquotte, Anne, Kim Overvad, Jacobs, Kevin B., Naomi E. Allen, Nadia Slimani, Olsson, Martin L, Amundadottir, Laufey, Stolzenberg-Solomon, Rachael Z, Fuchs, Charles S., Stephen J. Chanock, Mendelsohn, Julie B., Hoover, Robert N, Eric J. Jacobs, Hoover, Robert N., Hallmans, Goeran, Tobias, Geoffrey S., Wolpin, Brian M, David J. Hunter, Leah Sansbury, Dominique S. Michaud, Giovannucci, Edward L., Zheng, Wei, Shu, Xiao-Ou, Giovannucci, Edward L, Trichopoulos, Dimitrios, Arslan, Alan A, Patel, Alpa V, Hutchinson, Amy, Virtamo, Jarmo, Xu, Mousheng, Fuchs, Charles S, Hartge, Patricia, Alpa V. Patel, Overvad, Kim, Wolpin, Brian M., Sanchez, Maria-Jose, Wei Zheng, Kathy Helzlsouer, Gaziano, J. Michael, Olsson, Martin L., LaCroix, Andrea, Hunter, David J., Olsson, Martin L,, Arslan, Alan A., Paolo Vineis, Hunter, David J   +124 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

FUT2 non-secretor status is not associated with disease phenotype or outcomes in patients with Crohn’s disease

Crohn’s & Colitis 360
Abstract Purpose The fucosyltransferase 2 gene (FUT2) is responsible for the regulation of mucosal blood type antigens which can act as receptors for bacterial adhesion and regulate intestinal flora. A homozygous nonsense mutation in this gene leads to the absence of these antigens, termed FUT2
Rachel Lombard, Wenfei Wang, Alexander Chervonsky, Sushila Dalal, Russell D Cohen, Atsushi Sakuraba, David T Rubin, Christopher R Weber, Joel Pekow   +8 more
openaire   +2 more sources

Association of ABO, Lewis and Secretor Phenotypes and Genotypes with Neisseria gonorrhoeae [PDF]

, 2003
Previous studies of association of ABO phenotypes with gonorrhoea have shown contradictory results. Despite the interdependencies, none have examined the combined effect of ABO, Lewis and Secretor phenotypes.
Perry, Elizabeth Holly
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Third-Trimester Glucose Homeostasis in Healthy Women Is Differentially Associated with Human Milk Oligosaccharide Composition at 2 Months Postpartum by Secretor Phenotype

, 2020
Human milk oligosaccharides (HMOs) are bioactive molecules in human milk that play a critical role in infant health. Obesity and associated metabolic aberrations can negatively impact lactation and alter milk composition.
Lars Bode, Clark R. Sims, Ann Abraham, Aline Andres, Jessica L. Saben   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source