Results 61 to 70 of about 546,603 (232)

Host-Range Shif between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains

, 2020
International audienceIn Tunisia, we observed that rotavirus P[8]-3 and P[4] in young children with gastroenteritis associate with the secretor histo-blood-group phenotype.
Le Pendu, Jacques, Imbert-Marcille, Berthe-Marie, Breiman, Adrien, Mastouri, Maha, Peltier, Cécile, Khachou, Amira, Le Moullac-Vaidye, Béatrice, Aouni, Mahjoub, Chouchane, Slaheddine, Ruvoën-Clouet, Nathalie   +9 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

Genetics and Molecular Biology, 2002
The expression of the ABH and Lewis blood groups was determined in blood and saliva samples from two semi-isolated Black communities of Northern Brazil: Cametá and Alcântara.
Tereza Cristina OLiveira Corvelo, D.C.F. Aguiar, F.E.S. Sagica   +2 more
doaj   +1 more source

P[8] and P[4] Rotavirus Infection Associated with Secretor Phenotypes Among Children in South China

Scientific Reports, 2016
Abstract Rotaviruses are known to recognize human histo-blood group antigens (HBGAs) as a host ligand that is believed to play an important role in rotavirus host susceptibility and host range. In this study, paired fecal and saliva samples collected from children with viral gastroenteritis, as well as paired serum and saliva samples ...
Xu-Fu Zhang, Yan Long, Ming Tan, Ting Zhang, Qiong Huang, Xi Jiang, Wen-Fang Tan, Jian-Dong Li, Gui-Fang Hu, Shixing Tang, Ying-Chun Dai   +10 more
openaire   +2 more sources

KEGG Functional Pathways differentially abundant by mother’s secretor status.

, 2016
Differentially abundant KEGG Functional Pathways (LDA Effect Size > 2(log10)) in children’s PICRUSt predicted metagenome by mother secretor status (NS = non-secretor mother (n = 6), S = secretor mother (n = 11)), as calculated using LEfSe.
Paula Smith-Brown (3127242), Mark Morrison (159827), Peter S. W. Davies (2587675), Lutz Krause (11359)   +3 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source