Results 91 to 100 of about 546,603 (232)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Frontiers in NutritionPurposeTo investigate the human milk oligosaccharide (HMO) composition, longitudinal change and the influence of maternal factors in a multi-ethnic Asian cohort.MethodsIn the prospective GUSTO mother-offspring cohort, maternal sociodemographic, genetic ...
Han Zhang +30 more
doaj +1 more source
Global Journal of Transfusion Medicine, 2018 Background: Lewis (Le) antibodies are usually naturally occurring; however, they may be clinically significant, may be immunoglobulin G (IgG) type, and may cause hemolytic transfusion reactions.
Sudipta Sekhar Das, Ritam Chakrabarty
doaj +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Determination of ABO blood group based on secretors or non-secretors analysis in body fluids
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah SurabayaCriminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator.
Fery Setiawan +4 more
doaj +1 more source
, 2012 [[abstract]] We analyzed the seven mutations which are responsible for the deficiency of the secretor type α(1,2)-fucosyltransferase gene product, Se enzyme, in the Philippine population. One hundred and one unrelated Filipinos in Taiwan were studied.
Peng, C. T. ; Tsai, C. H. ; Lin, T. P. ; Perng, L. I. ; Kao, M. C. ; Yang, T. Y. ; Wang, Nancy M. ; Liu, T. C. ; Lin, S. F. ; Chang, J. G.
core
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Asian Journal of Transfusion Science, 2015 Context: Bombay blood group although rare is found to be more prevalent in the Western and Southern states of India, believed to be associated with consanguineous marriage.
Sujata Mallick +3 more
doaj +1 more source
Histo-blood group antigens and rotavirus vaccine virus shedding in Australian infants
, 2023 Rotavirus vaccine performance varies between high and low income countries. One possible explanation is inherited histo-blood group antigens (HBGAs) the expression of which differs between populations.
D M Whiley (13307013) +7 more
core