Results 221 to 230 of about 95,011 (288)
Variation and significance of secretory immunoglobulin A, interleukin 6 and dendritic cells in oral cancer. [PDF]
Oncol Lett, 2017 Zhang S +5 more
europepmc +1 more source
T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
wiley +1 more source
Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance
Aging Cell, Volume 25, Issue 5, May 2026.Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Fang Wu +10 more
wiley +1 more source
Can secretory immunoglobulin A in saliva predict a change in lung infection status in patients with cystic fibrosis? A prospective pilot study. [PDF]
Health Sci Rep, 2018 Alanin MC +8 more
europepmc +1 more source
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source
Andrology, Volume 14, Issue 4, Page 978-991, May 2026.Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre +5 more
wiley +1 more source
Site-specific glycosylation of secretory immunoglobulin A from human colostrum. [PDF]
J Proteome Res, 2015 Huang J +6 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4326-4334, May 2026.ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta +6 more
wiley +1 more source
Lifelong Exercise as a Modulator of CD4+ T Cell Immunometabolism
European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.Hypothetical framework illustrating how physical exercise initiated early in life acts as a critical immunomodulatory factor by promoting optimal immune function from childhood and establishing a better “immunometabolic functional peak”. This early advantage may confer sustained benefits to CD4+ T cell metabolism and immune competence across aging ...
Bruna Spolador de Alencar Silva +9 more
wiley +1 more source
European Journal of Neurology, Volume 33, Issue 5, May 2026.This study investigates four Chinese families with congenital insensitivity to pain with anhidrosis (CIPA). Through next‐generation sequencing, we identified seven NTRK1 variants, including two novel mutations. Functional characterization of five identified missense and indel variants revealed distinct disruptions in the NGF‐TrkA pathway, ranging from ...
Yaqiong Ren +9 more
wiley +1 more source