Results 41 to 50 of about 95,011 (288)

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Secretory immunoglobulin A from human milk hydrolyzes microRNA [PDF]

Journal of Dairy Science, 2020
For breast-fed infants, human milk is a source of various nutrients (e.g., proteins, peptides, antibodies) and bioactive components that promote neonatal growth and protect infants from viral and bacterial infection. Moreover, in terms of infant nutrition and protection the functions of many human milk components are very different from those of blood ...
Ivan Y. Kompaneets, Evgeny A. Ermakov, Sergey E. Sedykh, Valentina N. Buneva, Georgy A. Nevinsky   +4 more
openaire   +2 more sources

Non Secretory Myeloma with Acute Renal Failure- A Case Report

Journal of Clinical and Biomedical Sciences
Multiple myeloma, a cancer of plasma cell. They are usually two types; most common one is secretory type which is accounting to 95-97% & second one is non secretory type making up to 1-5%.
Megalamane Supreetha, Baburaj Swathi, Sriniramathi Rajadharshwan Udayakumar, Dhanapal Deepika   +3 more
doaj   +1 more source

DNA-hydrolyzing activity of sIgA-abzymes of human milk is differentially inhibited by nucleoside triphosphates

Біологічні студії, 2009
It is known that human milk contains secretory immunoglobulines A (sIgA-abzymes) possessing affinity to mammalian DNA and capacity to cleave plasmid DNA. Regulation of DNA-hydrolyzing activity of those sIgA-abzymes is poorly studied.
Yu. Ya. Kit
doaj   +1 more source

The multitasking framework: the effects of increasing workload on acute psychobiological stress reactivity [PDF]

, 2013
A variety of techniques exist for eliciting acute psychological stress in the laboratory; however, they vary in terms of their ease of use, reliability to elicit consistent responses and the extent to which they represent the stressors encountered in ...
Carter, Kirsty, Wetherell, Mark
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis

Cell Reports, 2021
Summary: Secretory immunoglobulin A (SIgA) can travel to and from the lumen and transport antigen to subepithelial cells. However, IgM can also multimerize into functional secretory component-bound immunoglobulin. While it is already known that both SIgA
Nicolas Rochereau, Eva Michaud, Louis Waeckel, Martin Killian, Rémi Gayet, Roman Goguyer-Deschaumes, Xavier Roblin, Gilles Biolley, Blaise Corthésy, Stéphane Paul   +9 more
doaj   +1 more source

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β [PDF]

, 2013
It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved.
Boon, Louis, Gloudemans, Anouk K, Guilliams, Martin, Hammad, Hamida, Harris, Nicola L, Hendriks, Rudi W, Hoogsteden, Henk C, Lambrecht, Bart, Ozir-Fazalalikhan, Arifa, Plantinga, Maud, Smits, Hermelijn H, van der Ham, Alwin, Willart, Monique, Yazdanbakhsh, Maria   +13 more
core   +8 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

CHANGES OF PROCALCITONIN LEVEL IN THE POST-TRAUMATIC PERIOD AND ITS ROLE IN SYSTEMIC RESPONSE TO TRAUMA

Вестник анестезиологии и реаниматологии, 2018
Procalcitonin is an important marker used in the clinical practice for sepsis diagnostics. However the increase of its concentration can be registered in the early post-traumatic period with no obvious nidus of infection.
Yu. S. Polushin, A. A. Afanasiev, I. V. Shlyk, L. P. Pivovarova, M. E. Malyshev   +4 more
doaj   +1 more source