Refolding, mutagenesis and characterisation of secretory phospholipase A2.
Bovine pancreatic phospholipase A2 (bPLA2) is a 14 kDa (123 amino acids) enzyme with seven disulphide bonds. Its primary function in vivo is the hydrolysis of dietary phospholipids.
Amrik. Basran (7700921)
core +3 more sources
Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats. [PDF]
Zhang S +6 more
europepmc +1 more source
Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice. [PDF]
Park HK +9 more
europepmc +1 more source
Secretory phospholipase A2 and neoantal di stress: pilot study on broncho-alveolar lavage
PURPOSES: Secretory phospholipase A2 hydrolyzes phosphoglycerides and it has been shown to be involved in alveolar inflammation and surfactant degradation.
Baroni, Silvia +9 more
core
Secretory phospholipase A2 (sPLA2) binds to and hydrolyzes cell membranes. It is important in inflammatory responses and diseases including septic shock, atherosclerosis, and cancer. Normally, cells resist the enzyme’s action, but they become susceptible
Bell, Dr. John
core
Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study.
This study sought to investigate the role of secretory phospholipase A2(sPLA2)-IIA in cardiovascular disease. Higher circulating levels of sPLA2-IIA mass or sPLA2enzyme activity have been associated with increased risk ofcardiovascular events.
Boekholdt, S.M. +111 more
core
ophthalmology, cell signaling, retinal degenerations, secretory phospholipase a2, sPLA2 ...
Bazan, N.G. +3 more
core +1 more source
Lipoprotein-associated phospholipase A2, vascular inflammation and cardiovascular risk prediction
Krishnankutty SudhirStanford University Medical Center, Stanford, CA, USAAbstract: Circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of inflammation that plays a critical role in atherogenesis; its inhibition may have ...
Krishnankutty Sudhir
core
Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from Crotalus durissus terrificus by Hispidulin from Moquiniastrum floribundum. [PDF]
Dos Santos Junior AB +6 more
europepmc +1 more source
Oxidized Phosphatidylcholines Regulate Secretory Phospholipase A<sub>2</sub> Through Membrane Nanodomain Remodeling. [PDF]
Yordanova V +7 more
europepmc +1 more source

