Results 101 to 110 of about 377,050 (209)

Indole-5-phenylcarbamate derivatives as human non-pancreatic secretory phospholipase A2 inhibitor

, 2005
The synthesis of the human non-pancreatic secretory phospholipase A2 inhibitor (IC50 = 1.81 +/- 0.59 mu M) is reported. (c) 2005 Elsevier Ltd.
Liu, Y, Xiao-feng Han, Huang, CK, Lu-Hua Lai, Ying Liu, Hao, X, Chang-kang Huang, Xin Hao, Han, XF, Lai, LH   +9 more
core   +1 more source

Divalent Cations Increase Lipid Order in Erythrocytes and Susceptibility to Secretory Phospholipase A2 [PDF]

, 2004
Elevated concentrations of intracellular calcium in erythrocytes increase membrane order and susceptibility to secretory phospholipase A2. We hypothesize that calcium aids the formation of domains of ordered lipids within erythrocyte membranes by ...
Allan M. Judd, Bell, John D., John D. Bell, Laurie J. Gonzales, Permann, Seth A., Gonzales, Laurie J., Hansen, Lee D., Seth A. Permann, Judd, Allan M., Rebekah S. Vest, Emily Spencer, Lee D. Hansen, Vest, Rebekah S., Spencer, Emily   +13 more
core   +1 more source

Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Journal of Tropical Medicine, 2018
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap ...
Tommaso C. Bulfone, Stephen P. Samuel, Philip E. Bickler, Matthew R. Lewin   +3 more
doaj   +1 more source

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretions⃞

Journal of Lipid Research, 2008
High density lipoprotein cholesterol represents a major source of biliary cholesterol. Secretory phospholipase A2 (sPLA2) is an acute phase enzyme mediating decreased plasma HDL cholesterol levels. Clinical studies reported a link between increased sPLA2
Uwe J.F. Tietge, Niels Nijstad, Rick Havinga, Julius F.W. Baller, Fjodor H. van der Sluijs, Vincent W. Bloks, Thomas Gautier, Folkert Kuipers   +7 more
doaj   +1 more source

A metabolomic investigation of the effects of vitamin E supplementation in humans [PDF]

, 2012
Background Vitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies.
John K Lodge, Max Wong, Lodge John K, Lodge, John, Wong, Max, Wong Max   +5 more
core   +3 more sources

Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus Venom Using Shotgun-Proteomics

Toxins, 2016
Tropidolaemus wagleri and Cryptelytrops purpureomaculatus are venomous pit viper species commonly found in Malaysia. Tandem mass spectrometry analysis of the crude venoms has detected different proteins in T. wagleri and C. purpureomaculatus.
Syafiq Asnawi Zainal Abidin, Pathmanathan Rajadurai, Md Ezharul Hoque Chowdhury, Muhamad Rusdi Ahmad Rusmili, Iekhsan Othman, Rakesh Naidu   +5 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancerResearch in context

EBioMedicine, 2019
Background: Tissue stem cells (SCs) and cancer cells proliferation is regulated by many common signalling mechanisms. These mechanisms temporally balance proliferation and differentiation events during normal tissue homeostasis and repair.
Gopal L. Chovatiya, Raghava R. Sunkara, Sayoni Roy, Saloni R. Godbole, Sanjeev K. Waghmare   +4 more
doaj   +1 more source

Secretory Phospholipase A2 Digital Expression Analysis in Colon Adenocarcinoma. [PDF]

In Vivo, 2022
Falidas E, Kitsiouli E, Spyropoulou D, Tsiambas E, Kalogirou A, Tsouvelas G, Papadopoulos S, Mitsis M, Lekka M, Mastronikoli S, Peschos D, Dimas O, Vlachos K.   +12 more
europepmc   +1 more source

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source