Results 81 to 90 of about 377,050 (209)

Antiphospholipid antibodies inhibit prostaglandin release by decidual cells of early pregnancy: possible involvement of extracellular secretory phospholipase A2.

, 1999
To investigate the effect of antiphospholipid antibodies on eicosanoid production by human decidual cells and the in vitro interaction between antiphospholipid antibodies and secretory phospholipase A2.Cultures of human decidual cells from early ...
Pierluigi Navarra, Emilia Pierro, Giuseppe Cirino, Natalia Lazzarin, Maria Rosaria Bucci, S. Mancuso, Cristiana Laura Andreani, A. Lanzone, CIRINO, GIUSEPPE, E. Pierro, Salvatore Mancuso, N. Lazzarin, Antonio Lanzone, BUCCI, MARIAROSARIA, P. Navarra, C. L. Andreani   +15 more
core   +1 more source

Biomarkers of atherosclerotic plaque vulnerability and their clinical significance

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Inflammatory reaction plays a crucial role in the occurence and development of atherosclerosis. Both basic and clinical trials have provided evidence that the expression of inflammatory biomarkers are closely related with the degree of atherosclerosis.
Ran LIU, Hong-jun HAO, Lin-lin LIU, Jing-jing LUO, Jie-xi WEN, Feng GAO   +5 more
doaj  

Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts

Mediators of Inflammation, 1995
Tenidap (TD) was initially defined as a dual inhibitor of cyclooxygenase and lipoxygenase. This study was designed to assess its inhibitory activity against proinflammatory phospholipase A2.
W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas   +5 more
doaj   +1 more source

Predicting the mechanism of phospholipidosis [PDF]

, 2012
The mechanism of phospholipidosis is still not well understood. Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.
Mitchell, JBO, Glen, RC, Glen Robert C, Nigsch Florian, Mussa, HY, Robert Lowe, Florian Nigsch, Robert C Glen, Nigsch, F, Mussa, Hamse Y., Lowe, R, Glen, Robert C., Lowe Robert, John BO Mitchell, Mitchell John BO, Nigsch, Florian, Lowe, Robert, Mussa Hamse Y, Hamse Y Mussa, Mitchell, John B. O.   +19 more
core   +5 more sources

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Exploration, Volume 6, Issue 4, August 2026.
Obesity‐linked hypercoagulation is driven by fibrinogen overproduction in a specific hepatocyte cluster via IL6 signalling. Genetic and mechanistic studies reveal this pathway as a key target for therapies to mitigate clotting risks and associated complications in obese individuals.
Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng, Ziyi Yang, Yue Liu, Yonghui Jiang, Tao Zhu, Teng Liu, Yunfei Xu, Chang Pan, Han Zhao, Shaozhuang Liu, Shigang Zhao, Zi‐Jiang Chen   +14 more
wiley   +1 more source

Therapeutic reduction of lysophospholipids in the digestive tract recapitulates the metabolic benefits of bariatric surgery and promotes diabetes remission

Molecular Metabolism, 2018
Objective: Obesity and obesity-related metabolic disorders are major health problems worldwide. The most effective obesity intervention is bariatric surgery.
James G. Cash, Eddy Konaniah, Narasimha Hegde, David G. Kuhel, Miki Watanabe, Lindsey Romick-Rosendale, David Y. Hui   +6 more
doaj   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source

Fecal Proteomics Suggest Potential Biomarkers for Non‐Alcoholic Fatty Liver Disease and Steatohepatitis

PROTEOMICS – Clinical Applications, Volume 20, Issue 4, July 2026.
ABSTRACT Background and aims Non‐alcoholic Fatty Liver Disease (NAFLD) affects about a quarter of the world's population. Liver biopsy remains the gold standard for diagnosing the progressive form of NAFLD called Non‐alcoholic Steatohepatitis (NASH) but it is invasive, prone to sampling errors and observer variability, and impractical for widespread ...
Anna Negroni, Luisa Pieroni, Noemi Fiaschini, Francesca Palone, Mariateresa Mancuso, Roberta Vitali   +5 more
wiley   +1 more source

Proteolysis of Apolipoprotein A-I by Secretory Phospholipase A2 [PDF]

Journal of Biological Chemistry, 2014
In the acute phase of the inflammatory response, secretory phospholipase A2 (sPLA2) reaches its maximum levels in plasma, where it is mostly associated with high density lipoproteins (HDL). Overexpression of human sPLA2 in transgenic mice reduces both HDL cholesterol and apolipoprotein A-I (apoA-I) plasma levels through increased HDL catabolism by an ...
Giorgio Cavigiolio, Shobini Jayaraman
openaire   +1 more source

Phospholipase A2 activity of pancreatic secretory factor, a new secretagogue isolated from the venom of Heloderma suspectum. [PDF]

, 1984
Pancreatic secretory factor (PSF), an efficient pancreatic secretagogue recently isolated from the venom of Heloderma suspectum, is shown to exert phospholipase A2 activity towards phosphatidylcholine.
Vandermeers-Piret, Marie-Claire, Christophe, Jean, Patrick Michel, Jacques Winand, Winand, Jacques, Catherine Damien, Vandermeers, André, Jean-Paul Dehaye, Piotr Poloczek, Marie-Claire Vandermeers-Piret, Dehaye, Jean-Paul, Michel, Patrick, Poloczek, Piotr, Damien, Catherine, André Vandermeers, Jean Christophe   +15 more
core   +1 more source