Results 71 to 80 of about 377,050 (209)

Identification of a Soluble Form Phospholipase A2Receptor as a Circulating Endogenous Inhibitor for Secretory Phospholipase A2 [PDF]

Journal of Biological Chemistry, 2002
Venomous snakes have various types of phospholipase A(2) inhibitory proteins (PLIs) in their circulatory system to protect them from attack by their own phospholipase A(2)s (PLA(2)s). Here we show the first evidence for the existence of circulating PLI against secretory PLA(2)s (sPLA(2)s) in mammals.
Ken-ichi, Higashino Ki, Yasunori, Yokota, Takashi, Ono, Shigeki, Kamitani, Hitoshi, Arita, Kohji, Hanasaki   +5 more
openaire   +2 more sources

Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants [PDF]

, 2013
Introduction: Secretory phospholipase A2 is supposed to play a role in acute lung injury but no data are available for pediatric acute respiratory distress syndrome (ARDS).
Gentile, Leonarda, De Luca, Daniele, Stival, Eleonora, Minucci, Angelo, Capoluongo, Ettore Domenico, Vendittelli, Francesca, Piastra, Marco, Antonelli, Massimo, Conti, Giorgio   +8 more
core   +1 more source

Inhibitory Effect of Three Diketopiperazines from Marine-derived Bacteria on Secretory Group IIA Phospholipase A2

Natural Product Communications, 2016
Diketopiperazines, natural products found in bacteria, fungi, marine sponges, gorgonian and red algae, are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains.
Hyukjae Choi, Sae-Kwang Ku, Jong-Sup Bae
doaj   +1 more source

Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL*

Journal of Lipid Research, 2009
We previously reported that LDL modified by group V secretory phospholipase A2 (GV-LDL) promotes macrophage foam cell formation through a mechanism independent of scavenger receptors SR-A and CD36, and dependent on cellular proteoglycans.
Boris B. Boyanovsky, Preetha Shridas, Michael Simons, Deneys R. van der Westhuyzen, Nancy R. Webb   +4 more
doaj   +1 more source

Phospholipases A1 [PDF]

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S.   +3 more
core   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury

, 2003
Induction of type-IIA secretory phospholipase A2 in animal models ...
Hôpital Henri Mondor, Delclaux, C., F. Thouron, Koumanov, K., M. Alaoui-el-azher, Attalah, H.L., Harf, A., Wolf, C., Alaoui-El-Azher, M., C. Wolf, L. Brochard, K. Koumanov, Brochard, L., Y. Wu, Touqui, L., C. Delclaux, Wu, Yongzheng, A. Harf, Injury H. L. Attalah, Thouron, F., Service De Réanimation Médicale   +20 more
core   +1 more source

Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 [PDF]

, 1998
Secretory phospholipase A2 (sPLA2) is the major effector involved in arachidonic acid (AA) mobilization and prostaglandin E2 (PGE2) production during stimulation of P388D1 macrophages with the inflammatory stimuli bacterial lipopolysaccharide and ...
Jesús Balsinde, Edward A. Dennis, Dennis, Edward A, María A. Balboa, Balboa, María A, Balsinde, Jesús   +5 more
core   +1 more source

Viperidae snake venom phospholipase A2. Biochemical targets in the human blood circulatory system. Review. Part 2

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
In this review (Part 2), we describe the structural features and properties of the most studied Viperidae snake venom phospholipases A2 . Various effects of these enzymes on blood cells (erythrocytes, leukocytes and platelets), on blood coagulation and ...
L. V. Vasina, L. V. Galebskaya, М. А. Galkin, М. А. Solovyeva, Yu. V. Tarasova   +4 more
doaj   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source