Results 51 to 60 of about 377,050 (209)

Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study

, 2011
Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a promising therapeutic target.
L Sanfeliciano, M Piastra, F Cools, V Rigo, L Gentile, M Antonelli, F Camfferman, G Conti, F Vendittelli, E Capoluongo, A Minucci, D Tripodi, Daniele De Luca, B Giardina, M F Benito Zaballos, C Zuppi, J T Carbajosa, A Remesal, Ettore Capoluongo, D Pietrini, Vincent Rigo and Study group on Secretory Phospholipase in Paediatrics (SSPP): D De Luca   +20 more
core   +1 more source

Role of membrane oxidation in controlling the activity of human group IIa secretory phospholipase A2 toward apoptotic lymphoma cells [PDF]

, 2013
The membranes of healthy lymphocytes normally resist hydrolysis by secretory phospholipase A2. However, they become susceptible during the process of apoptosis.
Anderson, Lynn, Gibbons, Elizabeth, Brewer, Kelly, Bell, John D., Melchor, Stephanie, Judd, Allan M., Nelson, Jennifer   +6 more
core   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation

Scientific Reports, 2017
Levels of secretory phospholipases A2 (sPLA2) highly increase under acute and chronic inflammatory conditions. sPLA2 is mainly associated with high-density lipoproteins (HDL) and generates bioactive lysophospholipids implicated in acute and chronic ...
Sanja Curcic, Michael Holzer, Lisa Pasterk, Eva Knuplez, Thomas O. Eichmann, Saša Frank, Robert Zimmermann, Rudolf Schicho, Akos Heinemann, Gunther Marsche   +9 more
doaj   +1 more source

Characterization of plasma secretory phospholipase A2 activity in the prairie rattlesnake (Crotalus viridis)

Journal of Basic and Applied Zoology, 2020
Background Plasma phospholipase A2 (PLA2) enzyme activity is a key component of innate immunity in most vertebrates. We evaluated circulating secreted PLA2 activity of prairie rattlesnakes (Crotalus viridis) by incubation of plasma with bacteria labeled ...
Sarah Baker, Mark Merchant
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

The electrostatic basis for the interfacial binding of secretory phospholipases A2

Biophysical Journal, 1994
Biochemical and structural data suggest that electrostatic forces play a critical role in the binding of secretory phospholipases A2 to substrate aggregates (micelles, vesicles, monolayers, and membranes). This initial binding (adsorption) of the enzyme to the interface is kinetically distinct from the subsequent binding of substrate to the buried ...
Scott, D.L., Mandel, A.M., Sigler, P.B., Honig, B.   +3 more
openaire   +2 more sources

Secretory Phospholipases A2 Activate Selective Functions in Human Eosinophils [PDF]

The Journal of Immunology, 2003
Abstract Secretory phospholipases A2 (sPLA2s) are released in large amounts in the blood of patients with systemic inflammatory diseases and accumulate at sites of chronic inflammation, such as the airways of patients with bronchial asthma.
TRIGGIANI, MASSIMO, Granata, Francescopaolo, Balestrieri, Barbara, Petraroli, Angelica, Scalia, Giulia, Del Vecchio, Luigi, Marone, Gianni   +6 more
openaire   +5 more sources

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Söderkvist, Peter, Gidlöf, Anders, Uhl, Eberhard, Carlsson, Maria, Öst, Martin, Sirsjö, Allan   +5 more
core   +1 more source