Results 41 to 50 of about 12,510 (211)

Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress

Journal of Lipid Research, 2005
Group IIA secretory phospholipase A2 (sPLA2) is an acute-phase protein mediating decreased plasma HDL cholesterol and increased atherosclerosis. This study investigated the impact of macrophage-specific sPLA2 overexpression on lipoprotein metabolism and ...
Uwe J.F. Tietge, Domenico Pratico, Tao Ding, Colin D. Funk, Reeni B. Hildebrand, Theo Van Berkel, Miranda Van Eck   +6 more
doaj   +1 more source

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

Natural Product Communications, 2018
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs ...
In-Chul Lee, Jong-Sup Bae
doaj   +1 more source

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

Journal of Lipid Research, 2010
LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and ...
Riia Plihtari, Eva Hurt-Camejo, Katariina Öörni, Petri T. Kovanen   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of Octahydroquinazolinones as Phospholipase A2, and Protease Inhibitors: Experimental and Theoretical Exploration

Molecules, 2023
Phospholipase A2 (PLA2) promotes inflammation via lipid mediators and releases arachidonic acid (AA), and these enzymes have been found to be elevated in a variety of diseases, including rheumatoid arthritis, sepsis, and atherosclerosis. The mobilization
Md. Afroz Bakht, Thangaiyan Pooventhiran, Renjith Thomas, Mehnaz Kamal, Israf Ud Din, Najeeb Ur Rehman, Imtiaz Ali, Noushin Ajmal, Mohamed Jawed Ahsan   +8 more
doaj   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants [PDF]

, 2013
Introduction: Secretory phospholipase A2 is supposed to play a role in acute lung injury but no data are available for pediatric acute respiratory distress syndrome (ARDS).
Gentile, Leonarda, De Luca, Daniele, Stival, Eleonora, Minucci, Angelo, Capoluongo, Ettore Domenico, Vendittelli, Francesca, Piastra, Marco, Antonelli, Massimo, Conti, Giorgio   +8 more
core   +1 more source

Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats

Journal of Pharmacological Sciences, 2004
We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats.
Yasuhiko Tomita, Kenji Kuwabara, Shingo Furue, Kazushige Tanaka, Katsutoshi Yamada, Masahiko Ueno, Takashi Ono, Toshiyuki Maruyama, Tetsuo Ajiki, Hirohiko Onoyama, Masahiro Yamamoto, Yozo Hori   +11 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study

, 2011
Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a promising therapeutic target.
L Sanfeliciano, M Piastra, F Cools, V Rigo, L Gentile, M Antonelli, F Camfferman, G Conti, F Vendittelli, E Capoluongo, A Minucci, D Tripodi, Daniele De Luca, B Giardina, M F Benito Zaballos, C Zuppi, J T Carbajosa, A Remesal, Ettore Capoluongo, D Pietrini, Vincent Rigo and Study group on Secretory Phospholipase in Paediatrics (SSPP): D De Luca   +20 more
core   +1 more source

Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 [PDF]

, 1998
Secretory phospholipase A2 (sPLA2) is the major effector involved in arachidonic acid (AA) mobilization and prostaglandin E2 (PGE2) production during stimulation of P388D1 macrophages with the inflammatory stimuli bacterial lipopolysaccharide and ...
Jesús Balsinde, Edward A. Dennis, Dennis, Edward A, María A. Balboa, Balboa, María A, Balsinde, Jesús   +5 more
core   +1 more source