Results 41 to 50 of about 377,050 (209)

Clearance of group X secretory phospholipase A2 via mouse phospholipase A2 receptor [PDF]

, 2001
Given the potent hydrolyzing activity toward phosphatidylcholine, group X secretory phospholipase A2 (sPLA2-X) elicits a marked release of arachidonic acid linked to the potent production of lipid mediators in various cell types.
Notoya, Mitsuru, Yasunori Yokota, Higashino, Ken-ichi, Hitoshi Arita, Nakano, Kazumi, Yokota, Yasunori, Ishimoto, Yoshikazu, Mitsuru Notoya, Kohji Hanasaki, Hanasaki, Kohji, Kazumi Nakano, Arita, Hitoshi, Ken-ichi Higashino, Yoshikazu Ishimoto   +13 more
core   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Gilfillan, Alasdair M., Kuehn, Hye Sun, Beaven, Michael A., Swindle, Emily J., Kim, Mi-Sun, Metcalfe, Dean D.   +5 more
core   +2 more sources

Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2

Natural Product Communications, 2018
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs ...
In-Chul Lee, Jong-Sup Bae
doaj   +1 more source

Relationship between membrane permeability and specificity of human secretory phospholipase A2 isoforms during cell death [PDF]

, 2011
During apoptosis, a number of physical changes occur in the cell membrane including a gradual increase in permeability to vital stains such as propidium iodide.
Allan M. Judd, Michael Streeter, Bell, John D., Yeung, Celestine H.-Y., Elizabeth Gibbons, John D. Bell, Celestine H.-Y. Yeung, Jennifer Nelson, Ashley O. Warcup, Gibbons, Elizabeth, Warcup, Ashley O., Streeter, Michael, Judd, Allan M., Pickett, Katalyn R., Nelson, Jennifer, Katalyn R. Pickett   +15 more
core   +1 more source

Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

Journal of Lipid Research, 2010
LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and ...
Riia Plihtari, Eva Hurt-Camejo, Katariina Öörni, Petri T. Kovanen   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of Octahydroquinazolinones as Phospholipase A2, and Protease Inhibitors: Experimental and Theoretical Exploration

Molecules, 2023
Phospholipase A2 (PLA2) promotes inflammation via lipid mediators and releases arachidonic acid (AA), and these enzymes have been found to be elevated in a variety of diseases, including rheumatoid arthritis, sepsis, and atherosclerosis. The mobilization
Md. Afroz Bakht, Thangaiyan Pooventhiran, Renjith Thomas, Mehnaz Kamal, Israf Ud Din, Najeeb Ur Rehman, Imtiaz Ali, Noushin Ajmal, Mohamed Jawed Ahsan   +8 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Inactivation of secretory phospholipase A2 by ionizing radiation

Biophysical Journal, 1995
The extracellular phospholipase A2s (PLA2) from cobra venom, rattlesnake venom, and porcine pancreas were analyzed by radiation inactivation to determine their functional aggregation states. The analysis was performed in the presence of the protein transferrin at two different concentrations of PLA2: 5 micrograms/ml.
Reynolds, LJ, Kempner, ES, Hughes, LL, Dennis, EA   +3 more
openaire   +4 more sources

Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats

Journal of Pharmacological Sciences, 2004
We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats.
Yasuhiko Tomita, Kenji Kuwabara, Shingo Furue, Kazushige Tanaka, Katsutoshi Yamada, Masahiko Ueno, Takashi Ono, Toshiyuki Maruyama, Tetsuo Ajiki, Hirohiko Onoyama, Masahiro Yamamoto, Yozo Hori   +11 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source