Results 21 to 30 of about 377,050 (209)

Spinal phospholipase A2 in inflammatory hyperalgesia: Role of the small, secretory phospholipase A2 [PDF]

Neuroscience, 2005
Current work emphasizes that peripheral tissue injury and inflammation results in a heightened sensitivity to subsequent noxious input (hyperalgesia) that is mediated in large part by the spinal synthesis and release of eicosanoids, in particular prostaglandins.
Svensson, CI, Lucas, KK, Hua, X-Y, Powell, HC, Dennis, EA, Yaksh, TL   +5 more
openaire   +4 more sources

Secretory Phospholipase A2s in Insulin Resistance and Metabolism [PDF]

Frontiers in Endocrinology, 2021
The phospholipases A2 (PLA2) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past, much of the research on secretory PLA2s has analyzed their roles in inflammation, anti-bacterial ...
openaire   +3 more sources

Secretory Phospholipase A2

Biological and Pharmaceutical Bulletin, 2004
Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA2 isozymes in mammals.
Murakami, Makoto, Kudo, Ichiro
openaire   +3 more sources

Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor

Journal of Pharmacological Sciences, 2011
Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated.
Yoshiyuki Tanabe, Maki Saito, Yuki Morikawa, Akihisa Kamataki, Takashi Sawai, Masamichi Hirose, Koichi Nakayama   +6 more
doaj   +1 more source

Secretory non-pancreatic phospholipase A2: influence on lipoprotein metabolism

Journal of Lipid Research, 1997
Lipoprotein metabolism is markedly altered during inflammation. The concentration of human secretory phospholipase A2 (sPLA2) can increase hundreds of fold in inflammatory fluids and in the circulation.
F C de Beer, M C de Beer, D R van der Westhuyzen, L W Castellani, A J Lusis, M E Swanson, D S Grass   +6 more
doaj   +1 more source

Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]

, 2002
Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Quintel, Michael, Samman, Michael, Bertsch, Thomas, Aufenanger, Johannes, Fassbender, Klaus, Zimmer, Wilma, Michael Samman, Klaus Fassbender, Michael Quintel, Thomas Bertsch, Johannes Aufenanger, Wilma Zimmer   +11 more
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Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ladds, Graham, Aletrari, Mina-Olga, Hodgkin, Matthew N., Farquhar, Michelle J., Wright, Michelle H.   +4 more
core   +1 more source

Mechanism(s) of activation of secretory phospholipase A2s in mouse keratinocytes

Journal of Lipid Research, 1999
The differential activation of different members of the phospholipase A2 (PLA2) superfamily and their regulation are important as one or more of them regulates the production of eicosanoids and others may contribute to the formation of other lipid ...
Bangyan Li-Stiles, Susan M. Fischer
doaj   +1 more source

Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL

Journal of Lipid Research, 1998
Group IIA secretory phospholipase A2 is an acute phase enzyme, co-expressed with serum amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal and acute phase high density lipoproteins and low density lipoprotein are ...
Waldemar Pruzanski, Eva Stefanski, Frederick C. de Beer, Maria C. de Beer, Peter Vadas, Amir Ravandi, Arnis Kuksis   +6 more
doaj   +1 more source

Secretory Phospholipase A2-IIA and Cardiovascular Disease [PDF]

Journal of the American College of Cardiology, 2013
This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease.Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal.
Holmes, M.V., Simon, T., Exeter, H.J., Folkersen, L., Asselbergs, F.W., Guardiola, M., Cooper, J.A., Palmen, J., Hubacek, J.A., Carruthers, K.F., Horne, B.D., Brunisholz, K.D., Mega, J.L., Iperen, E.P.A. van, Li, M.Y., Leusink, M., Trompet, S., Verschuren, J.J.W., Hovingh, G.K., Dehghan, A., Nelson, C.P., Kotti, S., Danchin, N., Scholz, M., Haase, C.L., Rothenbacher, D., Swerdlow, D.I., Kuchenbaecker, K.B., Staines-Urias, E., Goel, A., Hooft, F. van 't, Gertow, K., Faire, U. de, Panayiotou, A.G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L.M., Beutner, F., Gansevoort, R.T., Navis, G.J., Leach, I.M., Breitling, L.P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J.M.A., Stephens, J.W., Hofker, M.H., Tedgui, A., Hofman, A., Uitterlinden, A.G., Adamkova, V., Pitha, J., Onland-Moret, N.C., Cramer, M.J., Nathoe, H.M., Spiering, W., Klungel, O.H., Kumari, M., Whincup, P.H., Morrow, D.A., Braund, P.S., Hall, A.S., Olsson, A.G., Doevendans, P.A., Trip, M.D., Tobin, M.D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A.N., Teupser, D., Day, I.N.M., Carlquist, J.F., Gaunt, T.R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G.G., Lawlor, D.A., Morris, R.W., Sandhu, M.S., Poledne, R., Maitland-van der Zee, A.H., Khaw, K.T., Keating, B.J., Harst, P. van der, Price, J.F., Mehta, S.R., Yusuf, S., Witteman, J.C.M., Franco, O.H., Jukema, J.W., Knijff, P. de, Tybjaerg-Hansen, A., Rader, D.J., Farrall, M., Samani, N.J., Kivimaki, M., Fox, K.A.A., Humphries, S.E., Anderson, J.L., Boekholdt, S.M., Palmer, T.M., Eriksson, P., Pare, G., Hingorani, A.D., Sabatine, M.S., Mallat, Z., Casas, J.P., Talmud, P.J.   +112 more
openaire   +10 more sources