Suilyin Disrupts the Blood–Brain Barrier by Activating Group III Secretory Phospholipase A2 [PDF]
Life, 2022 Serious diseases caused by Streptococcus suis serotype 2 (S. suis 2) include septicaemia and meningitis, which are associated with high morbidity and mortality.
Yutong Sui +9 more
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Synergy between serum amyloid A and secretory phospholipase A2 [PDF]
eLife, 2019 Serum amyloid A (SAA) is an evolutionally conserved enigmatic biomarker of inflammation. In acute inflammation, SAA plasma levels increase ~1,000 fold, suggesting that this protein family has a vital beneficial role.
Shobini Jayaraman +2 more
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Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
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Secretory phospholipase A2-IIA targets bacterial extracellular vesicles to modulate immune signaling [PDF]
Communications BiologySecretory phospholipase A2-IIA (sPLA2-IIA) is a bactericidal enzyme that hydrolyzes membrane phospholipids, releasing lipid metabolites that can affect inflammation. sPLA2-IIA exhibits poor activity toward eukaryotic cells but preferentially targets gram-
Etienne Doré +16 more
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Isolation and Characterization of A2-EPTX-Nsm1a, a Secretory Phospholipase A2 from Malaysian Spitting Cobra (Naja sumatrana) Venom [PDF]
Toxins, 2021 Phospholipase A2 (PLA2) toxins are one of the main toxin families found in snake venom. PLA2 toxins are associated with various detrimental effects, including neurotoxicity, myotoxicity, hemostatic disturbances, nephrotoxicity, edema, and inflammation ...
Nur Atiqah Haizum Abdullah +5 more
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Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism [PDF]
Journal of Lipid Research, 2017 Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases that have been implicated in inflammation, atherogenesis, and antibacterial actions.
Michael S. Kuefner +9 more
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Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2 [PDF]
Molecules, 2017 Rhamnetin (Rhm), 3-O-methylquercetin (3MQ), and Rhamnazin (Rhz) are methylated derivatives of quercetin commonly found in fruits and vegetables that possess antioxidant and anti-inflammatory properties.
Mariana Novo Belchor +7 more
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Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2 [PDF]
Marine Drugs, 2019 Ellagitannins constitute the largest group of hydrolyzable tannins of plants, and, from this group, casuarictin (Casu) was identified in some plant species.
Caroline Fabri Bittencourt Rodrigues +9 more
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Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C) [PDF]
Experimental Biology and Medicine, 2021 Frans A Kuypers +2 more
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022 Snake venoms have been fervently studied for decades for two reasons: 1) high death rate due to snake bites; 2) numerous components of snake venoms prove useful in medicine and treatment of diverse pathologies. Snake venom phospholipases A2 are among the
L. V. Galebskaya +3 more
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