Results 11 to 20 of about 12,510 (211)

Secretory Phospholipases A2 in Plants [PDF]

Frontiers in Plant Science, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
María Elisa Mariani, María Elisa Mariani, María Elisa Mariani, Gerardo Daniel Fidelio, Gerardo Daniel Fidelio   +4 more
doaj   +4 more sources

Secretory Phospholipase A2 Tipe Ii (Spla Ii) pada Penyakit Kardiovaskuler

Majalah Kardiologi Indonesia, 2015
Reaksi inflamasi berperan dalam beberapa pathogenesis kondisi kardiovaskuler seperti atherosklerosis dan kerusakan iskemik pada infark miokard akut (IMA).
Djanggan Sargowo
doaj   +3 more sources

Quercetin As An Inhibitor Of Snake Venom Secretory Phospholipase A2

Chemico-Biological Interactions, 2015
As polyphenolic compounds isolated from plants extracts, flavonoids have been applied to various pharmaceutical uses in recent decades due to their anti-inflammatory, cancer preventive, and cardiovascular protective activities.
Baldissera Jr. L., Cotrim C.A., Toyama M.H., Diz Filho E.B.S., Hernandes M.Z., Monteiro H.S.A., De Oliveira Toyama D., Fonseca F.V., Rabello M.M., Ximenes R.M., De Oliveira S.C.B., Antunes E.   +11 more
core   +4 more sources

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels. [PDF]

PLoS ONE, 2012
BackgroundSecretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atherosclerosis in observational and animal studies. The protein is encoded by the PLA2G2A gene and the aim of this study was to test the functionality of ...
Holly J Exeter, Lasse Folkersen, Jutta Palmen, Anders Franco-Cereceda, Jackie A Cooper, Anastasia Z Kalea, Ferdinand Van't Hooft, Per Eriksson, Steve E Humphries, Philippa J Talmud   +9 more
doaj   +2 more sources

The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?

Vascular Health and Risk Management, 2008
Dimitar Divchev, Bernhard SchiefferDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, GermanyAbstract: Inflammation, lipid peroxidation and chronic activation of the renin–angiotensin system (RAS) are hallmarks of the ...
Dimitar Divchev, Bernhard Schieffer
doaj   +1 more source

Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts [PDF]

Mediators of Inflammation, 1995
Tenidap (TD) was initially defined as a dual inhibitor of cyclooxygenase and lipoxygenase. This study was designed to assess its inhibitory activity against proinflammatory phospholipase A2.
W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas   +5 more
doaj   +2 more sources

Secretory Phospholipase A₂ Enzymes in Acute Lung Injury. [PDF]

Cell Biochem Biophys, 2021
The secretory phospholipase A2 (sPLA2) group of secreted enzymes hydrolyze phospholipids and lead to the production of multiple biologically active lipid mediators. sPLA2s and their products (e.g., eicosanoids) play a significant role in the pathophysiology of various inflammatory diseases, including life-threatening lung disorders such as acute lung ...
Letsiou E, Htwe YM, Dudek SM.
europepmc   +4 more sources

Secretory phospholipase A2 in the pathogenesis of acute dengue infection. [PDF]

Immun Inflamm Dis, 2017
AbstractIntroductionPlatelet activating factor (PAF) is an important mediator of vascular leak in acute dengue. Phospholipase A2s (PLA2) are inflammatory lipid enzymes that generate and regulate PAF and other mediators associated with mast cells. We sought to investigate if mast cell activation and increases in secretory sPLA2s are associated with an ...
Jeewandara C, Gomes L, Udari S, Paranavitane SA, Shyamali NL, Ogg GS, Malavige GN.   +6 more
europepmc   +4 more sources

Cellular Distribution of Secreted Phospholipase A2 in Lungs of IPF Patients and Its Inhibition in Bleomycin-Induced Pulmonary Fibrosis in Mice

Cells, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a very poor prognosis as it has a 2.5 to 5 years mean survival after proper diagnosis. Even nintedanib and pirfenidone cannot halt the progression, though they slow the progression of IPF.
Ashish Jaiswal, Rakhshinda Rehman, Joytri Dutta, Sabita Singh, Archita Ray, Malathy Shridhar, Jaswant Jaisankar, Manas Bhatt, Dikshit Khandelwal, Bandya Sahoo, Arjun Ram, Ulaganathan Mabalirajan   +11 more
doaj   +1 more source

The Role of Serum Albumin and Secretory Phospholipase A2 in Sepsis. [PDF]

Int J Mol Sci
Sepsis is caused by a dysregulated host response to an infection that leads to cascading cell death and eventually organ failure. In this study, the role of inflammatory response serum secretory phospholipase A2 (sPLA2) and albumin in sepsis was investigated by determining the activities of the two proteins in serial serum samples collected on ...
Tsao FHC, Li Z, Amessoudji AW, Jawdat D, Sadat M, Arabi Y, Meyer KC.   +6 more
europepmc   +3 more sources