Results 11 to 20 of about 377,050 (209)

Secretory Phospholipases A2 in Plants [PDF]

Frontiers in Plant Science, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
María Elisa Mariani, María Elisa Mariani, María Elisa Mariani, Gerardo Daniel Fidelio, Gerardo Daniel Fidelio   +4 more
doaj   +4 more sources

Quercetin as an inhibitor of snake venom secretory phospholipase A2

Chemico-Biological Interactions, 2011
As polyphenolic compounds isolated from plants extracts, flavonoids have been applied to various pharmaceutical uses in recent decades due to their anti-inflammatory, cancer preventive, and cardiovascular protective activities. In this study, we evaluated the effects of the flavonoid quercetin on Crotalus durissus terrificus secretory phospholipase A2 (
Cotrim, Camila Aparecida, Buzzo de Oliveira, Simone Cristina, Diz Filho, Eduardo B. S., Fonseca, Fabiana Vieira, Baldissera, Lineu, Antunes, Edson, Ximenes, Rafael Matos, Azul Monteiro, Helena Serra, Rabello, Marcelo Montenegro, Hernandes, Marcelo Zaldini, Toyama, Daniela de Oliveira, Toyama, Marcos Hikari   +11 more
openaire   +4 more sources

Secretory Phospholipase A2 Tipe Ii (Spla Ii) pada Penyakit Kardiovaskuler [PDF]

Majalah Kardiologi Indonesia, 2015
Reaksi inflamasi berperan dalam beberapa pathogenesis kondisi kardiovaskuler seperti atherosklerosis dan kerusakan iskemik pada infark miokard akut (IMA).
Djanggan Sargowo
doaj   +2 more sources

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels. [PDF]

PLoS ONE, 2012
BackgroundSecretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atherosclerosis in observational and animal studies. The protein is encoded by the PLA2G2A gene and the aim of this study was to test the functionality of ...
Holly J Exeter, Lasse Folkersen, Jutta Palmen, Anders Franco-Cereceda, Jackie A Cooper, Anastasia Z Kalea, Ferdinand Van't Hooft, Per Eriksson, Steve E Humphries, Philippa J Talmud   +9 more
doaj   +2 more sources

The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?

Vascular Health and Risk Management, 2008
Dimitar Divchev, Bernhard SchiefferDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, GermanyAbstract: Inflammation, lipid peroxidation and chronic activation of the renin–angiotensin system (RAS) are hallmarks of the ...
Dimitar Divchev, Bernhard Schieffer
doaj   +1 more source

Secretory phospholipase A2 in the pathogenesis of acute dengue infection. [PDF]

Immun Inflamm Dis, 2017
AbstractIntroductionPlatelet activating factor (PAF) is an important mediator of vascular leak in acute dengue. Phospholipase A2s (PLA2) are inflammatory lipid enzymes that generate and regulate PAF and other mediators associated with mast cells. We sought to investigate if mast cell activation and increases in secretory sPLA2s are associated with an ...
Jeewandara C, Gomes L, Udari S, Paranavitane SA, Shyamali NL, Ogg GS, Malavige GN.   +6 more
europepmc   +4 more sources

Cellular Distribution of Secreted Phospholipase A2 in Lungs of IPF Patients and Its Inhibition in Bleomycin-Induced Pulmonary Fibrosis in Mice

Cells, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a very poor prognosis as it has a 2.5 to 5 years mean survival after proper diagnosis. Even nintedanib and pirfenidone cannot halt the progression, though they slow the progression of IPF.
Ashish Jaiswal, Rakhshinda Rehman, Joytri Dutta, Sabita Singh, Archita Ray, Malathy Shridhar, Jaswant Jaisankar, Manas Bhatt, Dikshit Khandelwal, Bandya Sahoo, Arjun Ram, Ulaganathan Mabalirajan   +11 more
doaj   +1 more source

The Role of Serum Albumin and Secretory Phospholipase A2 in Sepsis. [PDF]

Int J Mol Sci
Sepsis is caused by a dysregulated host response to an infection that leads to cascading cell death and eventually organ failure. In this study, the role of inflammatory response serum secretory phospholipase A2 (sPLA2) and albumin in sepsis was investigated by determining the activities of the two proteins in serial serum samples collected on ...
Tsao FHC, Li Z, Amessoudji AW, Jawdat D, Sadat M, Arabi Y, Meyer KC.   +6 more
europepmc   +3 more sources

The localization of phospholipase A2 in the secretory granule [PDF]

Biochemical Journal, 1994
A heat-resistant phospholipase A2 has been detected in the secretory granules of the mast cell [Chock, Rhee, Tang and Schmauder-Chock (1991) Eur. J. Biochem. 195, 707-713]. By using ultrastructural immunocytochemical techniques, we have now localized this enzyme to the matrix of the secretory granule. Like the cyclo-oxygenase [Schmauder-Chock and Chock
S P, Chock, E A, Schmauder-Chock, E, Cordella-Miele, L, Miele, A B, Mukherjee   +4 more
openaire   +2 more sources

Biology of secretory phospholipase A2. [PDF]

Cardiovasc Drugs Ther, 2009
The secretory phospholipase A(2) (sPLA(2)) family provides a seemingly endless array of potential biological functions that is only beginning to be appreciated. In humans, this family comprises 9 different members that vary in their tissue distribution, hydrolytic activity, and phospholipid substrate specificity.
Boyanovsky BB, Webb NR.
europepmc   +4 more sources