Results 31 to 40 of about 12,510 (211)

Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL

Journal of Lipid Research, 1998
Group IIA secretory phospholipase A2 is an acute phase enzyme, co-expressed with serum amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal and acute phase high density lipoproteins and low density lipoprotein are ...
Waldemar Pruzanski, Eva Stefanski, Frederick C. de Beer, Maria C. de Beer, Peter Vadas, Amir Ravandi, Arnis Kuksis   +6 more
doaj   +1 more source

Cellular source of human platelet secretory phospholipase A2 [PDF]

British Journal of Haematology, 1998
Platelets are one source of the group II extracellular form of phospholipase A2 (sPLA2) which is involved in the amplification of local and systemic inflammation. Although sPLA2 protein has been described in human platelets, its presence in human megakaryocytes has not been yet established. We demonstrated in this study that the human erythroleukaemia (
S, Emadi, M, Mirshahi, I, Elalamy, C, Nicolas, B B, Vargaftig, M, Hatmi   +5 more
openaire   +2 more sources

The synergistic inhibition of atherogenesis in apoE−/− mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)[S]

Journal of Lipid Research, 2009
Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease.
Zory Shaposhnik, Xuping Wang, Joaquim Trias, Heather Fraser, Aldons J. Lusis   +4 more
doaj   +1 more source

Secretory phospholipase A2: a biomarker of inflammation in autoimmune, bacterial and viral diseases

Медицинская иммунология, 2022
Secretory phospholipases A2 (sPLA2) represent a large superfamily of enzymes with a molecular weight of 14-19 kDa, including 15 groups and more than 30 isoforms belonging to four types: secretory (sPLA2), cytosolic (cPLA2), calcium-independent (iPLA2 ...
S. P. Urazov, A. N. Chernov, A. V. Cherkas, A. V. Boikov, O. S. Glotov, S. V. Apalko, N. N. Sushentseva, I. A. Polkovnikova, V. V. Smirnov, S. G. Shcherbak   +9 more
doaj   +1 more source

Immunohistochemical study on the secretory host defense system with lysozyme and secretory phospholipase A2 throughout rat respiratory tract. [PDF]

J Vet Med Sci, 2018
The host defense system with lysozyme and secretory phospholipase A2 (sPLA2) was immunohistochemically investigated in rat respiratory tract under healthy conditions. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NC)
Masuda N, Mantani Y, Yoshitomi C, Yuasa H, Nishida M, Arai M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H.   +9 more
europepmc   +2 more sources

Secretory Phospholipase A2 Tipe II (SPLA II) In Cardiovascular Disease

Majalah Kardiologi Indonesia, 2015
Inflammatory reactions contribute to the pathogenesis of cardiovascular conditions such as atherosclerosis and ischemic damage in acute myocardial infarction (AMI).
Djanggan Sargowo
doaj   +1 more source

Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Cellular Oncology, 2009
Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends
Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier   +7 more
doaj   +1 more source

Inactivation of secretory phospholipase A2 by ionizing radiation

Biophysical Journal, 1995
The extracellular phospholipase A2s (PLA2) from cobra venom, rattlesnake venom, and porcine pancreas were analyzed by radiation inactivation to determine their functional aggregation states. The analysis was performed in the presence of the protein transferrin at two different concentrations of PLA2: 5 micrograms/ml.
Reynolds, LJ, Kempner, ES, Hughes, LL, Dennis, EA   +3 more
openaire   +4 more sources

Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition

Journal of Lipid Research, 2005
Atherosclerosis is a chronic inflammatory disease of the vessel wall characterized by the accumulation of lipid-laden macrophages and fibrotic material.
Stijn A.I. Ghesquiere, Marion J.J. Gijbels, Marit Anthonsen, Patrick J.J. van Gorp, Ingeborg van der Made, Berit Johansen, Marten H. Hofker, Menno P.J. de Winther   +7 more
doaj   +1 more source

Inhibitory Effect of Zingerone on Secretory Group IIA Phospholipase A2

Natural Product Communications, 2017
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs ...
In-Chul Lee, Dae Yong Kim, Jong-Sup Bae
doaj   +1 more source