Results 31 to 40 of about 377,050 (209)

The synergistic inhibition of atherogenesis in apoE−/− mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)[S]

Journal of Lipid Research, 2009
Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease.
Zory Shaposhnik, Xuping Wang, Joaquim Trias, Heather Fraser, Aldons J. Lusis   +4 more
doaj   +1 more source

Secretory phospholipase A2: a biomarker of inflammation in autoimmune, bacterial and viral diseases

Медицинская иммунология, 2022
Secretory phospholipases A2 (sPLA2) represent a large superfamily of enzymes with a molecular weight of 14-19 kDa, including 15 groups and more than 30 isoforms belonging to four types: secretory (sPLA2), cytosolic (cPLA2), calcium-independent (iPLA2 ...
S. P. Urazov, A. N. Chernov, A. V. Cherkas, A. V. Boikov, O. S. Glotov, S. V. Apalko, N. N. Sushentseva, I. A. Polkovnikova, V. V. Smirnov, S. G. Shcherbak   +9 more
doaj   +1 more source

Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A2 [PDF]

, 2010
ObjectiveEsophageal adenocarcinoma is thought to arise from lesions produced by chronic esophageal inflammation. Secretory phospholipase A2 is an important mediator of mucosal response to gastroesophageal reflux, but its role in the function of mature ...
Fullerton, David A., Meng, Xianzhong, Johnson, Thomas, Weyant, Michael J., Mauchley, David   +4 more
core   +1 more source

Secretory Phospholipase A2 Tipe II (SPLA II) In Cardiovascular Disease

Majalah Kardiologi Indonesia, 2015
Inflammatory reactions contribute to the pathogenesis of cardiovascular conditions such as atherosclerosis and ischemic damage in acute myocardial infarction (AMI).
Djanggan Sargowo
doaj   +1 more source

Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Cellular Oncology, 2009
Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends
Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier   +7 more
doaj   +1 more source

Investigating the functions of Phospholipase C-1, Ca2+/H+ exchanger, and Secretory Phospholipase A2 in growth, stress responses, and cellulose degradation in Neurospora crassa [PDF]

, 2023
Supervisor: Tamuli, RanjanThesis Title: Investigating the functions of Phospholipase C-1, Ca2+/H+ exchanger, and Secretory Phospholipase A2 in growth, stress responses, and cellulose degradation in Neurospora ...
Baruah, Darshana
core   +1 more source

Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition

Journal of Lipid Research, 2005
Atherosclerosis is a chronic inflammatory disease of the vessel wall characterized by the accumulation of lipid-laden macrophages and fibrotic material.
Stijn A.I. Ghesquiere, Marion J.J. Gijbels, Marit Anthonsen, Patrick J.J. van Gorp, Ingeborg van der Made, Berit Johansen, Marten H. Hofker, Menno P.J. de Winther   +7 more
doaj   +1 more source

Cellular source of human platelet secretory phospholipase A2 [PDF]

British Journal of Haematology, 1998
Platelets are one source of the group II extracellular form of phospholipase A2 (sPLA2) which is involved in the amplification of local and systemic inflammation. Although sPLA2 protein has been described in human platelets, its presence in human megakaryocytes has not been yet established. We demonstrated in this study that the human erythroleukaemia (
S, Emadi, M, Mirshahi, I, Elalamy, C, Nicolas, B B, Vargaftig, M, Hatmi   +5 more
openaire   +2 more sources

Inhibitory Effect of Zingerone on Secretory Group IIA Phospholipase A2

Natural Product Communications, 2017
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs ...
In-Chul Lee, Dae Yong Kim, Jong-Sup Bae
doaj   +1 more source

Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress

Journal of Lipid Research, 2005
Group IIA secretory phospholipase A2 (sPLA2) is an acute-phase protein mediating decreased plasma HDL cholesterol and increased atherosclerosis. This study investigated the impact of macrophage-specific sPLA2 overexpression on lipoprotein metabolism and ...
Uwe J.F. Tietge, Domenico Pratico, Tao Ding, Colin D. Funk, Reeni B. Hildebrand, Theo Van Berkel, Miranda Van Eck   +6 more
doaj   +1 more source