Results 61 to 70 of about 377,050 (209)

Role of Secretory Phospholipase A2 in Rhythmic Contraction of Pulmonary Arteries of Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension

Journal of Pharmacological Sciences, 2012
Excessive stretching of the vascular wall in accordance with pulmonary arterial hypertension (PAH) induces a variety of pathogenic cellular events in the pulmonary arteries.
Yoshiyuki Tanabe, Maki Saito-Tanji, Yuki Morikawa, Akihisa Kamataki, Takashi Sawai, Koichi Nakayama   +5 more
doaj   +1 more source

Neuroprotective effect of phospholipase A2 from Malaysian Naja sumatrana venom against H2O2-induced cell damage and apoptosis

Frontiers in Pharmacology, 2022
Oxidative stress is one of the factors involved in the pathogenesis of several neurodegenerative diseases. It has been reported that a secretory phospholipase A2 known as A2-EPTX-NSm1a has lower cytotoxicity in neuronal cells compared to its crude Naja ...
Nur Atiqah Haizum Abdullah, Nur Atiqah Haizum Abdullah, Nur Qisya Afifah Veronica Sainik, Ezalia Esa, Nur Afrina Muhamad Hendri, Muhamad Rusdi Ahmad Rusmili, Wayne C. Hodgson, Mohd Farooq Shaikh, Iekhsan Othman   +8 more
doaj   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats

, 2006
The development of fibrosis in the chronically hypertensive heart is associated with infiltration of inflammatory cells and cardiac hypertrophy. In this study, an inhibitor of the proinflammatory enzyme, group IIA human secretory phospholipase A2 (sPLA2 ...
Fairlie, David P., Brown, Lindsay, Reid, Robert C., Rolfe, Barbara E., Levick, Scott, Loch, David, Taylor, Stephen M.   +6 more
core   +1 more source

Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death

Journal of Lipid Research, 2006
Globoid cell leukodystrophy (Krabbe disease) is an inherited neurological disorder caused by the pathogenomic accumulation of psychosine (galactosylsphingosine), a substrate for the deficient enzyme galactocerebroside β-galactosidase.
S. Giri, M. Khan, R. Rattan, I. Singh, A.K. Singh   +4 more
doaj   +1 more source

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods [PDF]

, 2008
Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase ...
Dozier, Zijun Lan
core  

Anti‐inflammatory agents in atherosclerosis—and a need for reform: Extraordinary claims require extraordinary evidence

Journal of Internal Medicine, Volume 300, Issue 3, Page 258-283, September 2026.
Abstract Since 1858, human atherosclerotic plaques have been shown to contain immune cells. But are these cells suitable therapeutic targets? Dozens of clinical trials of anti‐inflammatory agents other than colchicine have been performed in patients with clinically evident atherosclerosis.
Kevin Jon Williams
wiley   +1 more source

Structure and Catalytic Mechanism of Secretory Phospholipases A2

, 1994
Publisher Summary This chapter focuses on the aspects of phospholipases A 2 (sPLA 2 ) structure that are of particular relevance to catalysis. A formal reaction pathway based largely on high-resolution structure analysis of crystalline complexes of secretory phospholipids (sPLA 2 s) with a transition-state analog is proposed.
D L, Scott, P B, Sigler
openaire   +2 more sources