Results 31 to 40 of about 3,296 (190)

Secretory phospholipase A2: a biomarker of inflammation in autoimmune, bacterial and viral diseases

Медицинская иммунология, 2022
Secretory phospholipases A2 (sPLA2) represent a large superfamily of enzymes with a molecular weight of 14-19 kDa, including 15 groups and more than 30 isoforms belonging to four types: secretory (sPLA2), cytosolic (cPLA2), calcium-independent (iPLA2 ...
S. P. Urazov, A. N. Chernov, A. V. Cherkas, A. V. Boikov, O. S. Glotov, S. V. Apalko, N. N. Sushentseva, I. A. Polkovnikova, V. V. Smirnov, S. G. Shcherbak   +9 more
doaj   +1 more source

Secretory Phospholipase A2

Biological and Pharmaceutical Bulletin, 2004
Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA2 isozymes in mammals.
Murakami, Makoto, Kudo, Ichiro
openaire   +3 more sources

Secretory Phospholipase A2-IIA and Cardiovascular Disease [PDF]

Journal of the American College of Cardiology, 2013
Objectives:\ud This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease.<p></p>\ud \ud Background:\ud Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events.
Holmes, M.V., Simon, T., Exeter, H.J., Folkersen, L., Asselbergs, F.W., Guardiola, M., Cooper, J.A., Palmen, J., Hubacek, J.A., Carruthers, K.F., Horne, B.D., Brunisholz, K.D., Mega, J.L., Iperen, E.P.A. van, Li, M.Y., Leusink, M., Trompet, S., Verschuren, J.J.W., Hovingh, G.K., Dehghan, A., Nelson, C.P., Kotti, S., Danchin, N., Scholz, M., Haase, C.L., Rothenbacher, D., Swerdlow, D.I., Kuchenbaecker, K.B., Staines-Urias, E., Goel, A., Hooft, F. van 't, Gertow, K., Faire, U. de, Panayiotou, A.G., Tremoli, E., Baldassarre, D., Veglia, F., Holdt, L.M., Beutner, F., Gansevoort, R.T., Navis, G.J., Leach, I.M., Breitling, L.P., Brenner, H., Thiery, J., Dallmeier, D., Franco-Cereceda, A., Boer, J.M.A., Stephens, J.W., Hofker, M.H., Tedgui, A., Hofman, A., Uitterlinden, A.G., Adamkova, V., Pitha, J., Onland-Moret, N.C., Cramer, M.J., Nathoe, H.M., Spiering, W., Klungel, O.H., Kumari, M., Whincup, P.H., Morrow, D.A., Braund, P.S., Hall, A.S., Olsson, A.G., Doevendans, P.A., Trip, M.D., Tobin, M.D., Hamsten, A., Watkins, H., Koenig, W., Nicolaides, A.N., Teupser, D., Day, I.N.M., Carlquist, J.F., Gaunt, T.R., Ford, I., Sattar, N., Tsimikas, S., Schwartz, G.G., Lawlor, D.A., Morris, R.W., Sandhu, M.S., Poledne, R., Maitland-van der Zee, A.H., Khaw, K.T., Keating, B.J., Harst, P. van der, Price, J.F., Mehta, S.R., Yusuf, S., Witteman, J.C.M., Franco, O.H., Jukema, J.W., Knijff, P. de, Tybjaerg-Hansen, A., Rader, D.J., Farrall, M., Samani, N.J., Kivimaki, M., Fox, K.A.A., Humphries, S.E., Anderson, J.L., Boekholdt, S.M., Palmer, T.M., Eriksson, P., Pare, G., Hingorani, A.D., Sabatine, M.S., Mallat, Z., Casas, J.P., Talmud, P.J.   +112 more
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Synaptic lipid signaling

Journal of Lipid Research, 2003
Neuronal cellular and intracellular membranes are rich in specialized phospholipids that are reservoirs of lipid messengers released by specific phospholipases and stimulated by neurotransmitters, neurotrophic factors, cytokines, membrane depolarization,
Nicolas G. Bazan
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Calcium-independent phospholipases A2 and their roles in biological processes and diseases

Journal of Lipid Research, 2015
Among the family of phospholipases A2 (PLA2s) are the Ca2+-independent PLA2s (iPLA2s) and they are designated group VI iPLA2s. In relation to secretory and cytosolic PLA2s, the iPLA2s are more recently described and details of their expression and roles ...
Sasanka Ramanadham, Tomader Ali, Jason W. Ashley, Robert N. Bone, William D. Hancock, Xiaoyong Lei   +5 more
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Cellular source of human platelet secretory phospholipase A2 [PDF]

British Journal of Haematology, 1998
Platelets are one source of the group II extracellular form of phospholipase A2 (sPLA2) which is involved in the amplification of local and systemic inflammation. Although sPLA2 protein has been described in human platelets, its presence in human megakaryocytes has not been yet established. We demonstrated in this study that the human erythroleukaemia (
S, Emadi, M, Mirshahi, I, Elalamy, C, Nicolas, B B, Vargaftig, M, Hatmi   +5 more
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Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase

Journal of Lipid Research, 2010
LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and ...
Riia Plihtari, Eva Hurt-Camejo, Katariina Öörni, Petri T. Kovanen   +3 more
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Macrophage polarization is linked to Ca2+-independent phospholipase A2β-derived lipids and cross-cell signaling in mice[S]

Journal of Lipid Research, 2020
Phospholipases A2 (PLA2s) catalyze hydrolysis of the sn-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids.
Alexander J. Nelson, Daniel J. Stephenson, Christopher L. Cardona, Xiaoyong Lei, Abdulaziz Almutairi, Tayleur D. White, Ying G. Tusing, Margaret A. Park, Suzanne E. Barbour, Charles E. Chalfant, Sasanka Ramanadham   +10 more
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Secretory phospholipase A2 in the pathogenesis of acute dengue infection [PDF]

Immunity, Inflammation and Disease, 2016
AbstractIntroductionPlatelet activating factor (PAF) is an important mediator of vascular leak in acute dengue. Phospholipase A2s (PLA2) are inflammatory lipid enzymes that generate and regulate PAF and other mediators associated with mast cells. We sought to investigate if mast cell activation and increases in secretory sPLA2s are associated with an ...
Jeewandara, Chandima, Gomes, Laksiri, Udari, Sukhitha, Paranavitane, S.A., Shyamali, N.L.A., Ogg, Graham S., Malavige, Gathsaurie Neelika   +6 more
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Secretory phospholipase A2 group IIA modulates insulin sensitivity and metabolism

Journal of Lipid Research, 2017
Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases that have been implicated in inflammation, atherogenesis, and antibacterial actions.
Michael S. Kuefner, Kevin Pham, Jeanna R. Redd, Erin J. Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshall B. Elam, Edwards A. Park   +9 more
doaj   +1 more source