Results 171 to 180 of about 71,348 (257)

Therapeutic potential of mesenchymal stem cells in peripheral nerve injuries in horses

Equine Veterinary Education, EarlyView.
Summary Peripheral nerve injuries (PNI) in horses represent a significant clinical challenge, frequently associated with functional deficits and reduced athletic performance. Conventional therapeutic approaches, primarily based on anti‐inflammatory treatments and rehabilitation, offer limited efficacy, driving the search for innovative alternatives. In
L. V. de Oliveira Ferreira, R. Martins Amorim   +1 more
wiley   +1 more source

Endoscopically assessed mucus parameters in equine asthma: Relationship to clinical history and cytological findings data

Equine Veterinary Journal, EarlyView.
Abstract Background Mucus parameters are hallmark diagnostic features of equine asthma (EA). Objectives To investigate the relationship between mucus quantity score and mucus viscosity score with signalment, history, clinical findings and cytological parameters. Study Design Retrospective cross‐sectional study.
Julia Drespling, Leonie Berwanger, Heike Kühn, Bianca Schwarz, Marcus Doherr, Lars Mundhenk   +5 more
wiley   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

The koala (Phascolarctos cinereus) prostate: a proteomic perspective on gland segmentation. [PDF]

Biol Reprod
Campbell Y, Johnston SD, Palmieri C, Pini T.   +3 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Rethinking the Yeast Endomembrane System. [PDF]

Subcell Biochem
Glick BS.
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

The Golgi apparatus: adaptations to neuronal shape and functions. [PDF]

EMBO J
Subkhangulova A, Mikhaylova M.
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production. [PDF]

Cell Syst
Masson H, Tat J, Di Giusto P, Antonakoudis A, Shamie I, Baghdassarian H, Samoudi M, Robinson CM, Kuo CC, Koga N, Singh S, Gezalyan A, Li Z, Movsessian A, Richelle A, Lewis NE.   +15 more
europepmc   +1 more source