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Divergent Roles of HIF-1α and HIF-2α in Embryonic Development and Early Pregnancy. [PDF]
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Lipids and Secretory Vesicle Exocytosis
2023In recent years, the number of studies implicating lipids in the regulation of synaptic vesicle exocytosis has risen considerably. It has become increasingly clear that lipids such as phosphoinositides, lysophospholipids, cholesterol, arachidonic acid and myristic acid play critical regulatory roles in the processes leading up to exocytosis. Lipids may
Isaac O, Akefe +4 more
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Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles
Current Opinion in Cell Biology, 1993The formation of constitutive secretory vesicles and secretory granules from the trans-Golgi network is inhibited by brefeldin A, suggesting a role for ADP ribosylation factor and other coat proteins in the budding process, and is regulated by multiple heterotrimeric G proteins.
R, Bauerfeind, W B, Huttner
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Ca2+ and secretory-vesicle dynamics
Trends in Neurosciences, 1995Exocytosis in neurones and neuroendocrine cells is triggered by an increase in the cytosolic concentration of Ca2+, and is followed by endocytotic membrane retrieval. Electrophysiological studies have characterized the nature of the Ca2+ signal that is required for exocytosis, and have defined the Ca(2+)-dependent steps in exocytotic and endocytotic ...
R D, Burgoyne, A, Morgan
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Serotonin‐Storing Secretory Vesiclesa
Annals of the New York Academy of Sciences, 1990Advances have been made in the characterization of 5-HT-storing organelles of neurectodermal cells. The parafollicular cell of the thyroid has been used as a model. This cell stores 5-HT, shares many properties with neurons, and can be induced to change its phenotype from endocrine to neuronal by exposure in vitro to NGF.
H, Tamir, M D, Gershon
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Human neutrophil granules and secretory vesicles
European Journal of Haematology, 1993Abstract: The traditional classification of neutrophil granules as peroxidase‐positive (azurophil, or primary) and peroxidase‐negative (specific or secondary) has proven to be too simple to explain the differential exocytosis of granule proteins and incorporation of granule membrane into the plasma membrane which is an important aspect of neutrophil ...
N, Borregaard +6 more
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Neutrophil granules and secretory vesicles in inflammation
Microbes and Infection, 2003The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the destruction of phagocytosed microorganisms. Neutrophil granules contain a multitude of antimicrobial and potentially cytotoxic substances that are delivered to the ...
Mikkel, Faurschou, Niels, Borregaard
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Aquaporin regulation: Lessons from secretory vesicles
2020Secretory vesicle swelling has been demonstrated to be a requirement in cell secretion. In the past 25 years, the quest to elucidate the molecular mechanism of secretory vesicle swelling, serendipitously revealed the presence of water channels or aquaporins at the secretory vesicle membrane and their involvement in rapid gaiting of water into secretory
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Isolation of secretory vesicles from Saccharomyces cerevisiae
Analytical Biochemistry, 1987Purification of secretory vesicles from Saccharomyces cerevisiae has been hindered because these organelles normally represent a small proportion of cellular membranes. In the yeast secretory mutant sec1, secretory vesicles accumulate intracellularly in large quantities.
C L, Holcomb, T, Etcheverry, R, Schekman
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