Results 91 to 100 of about 1,746,741 (337)
Қарағанды университетінің хабаршысы. Математика сериясыIn the present paper sets related to invariant Riemannian metrics of positive sectional and (or) Ricci curvature on generalized Wallach spaces are considered.
N.A. Abiev
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Sectional curvature for Riemannian manifolds with density [PDF]
, 2013 In this paper we introduce two new notions of sectional curvature for Riemannian manifolds with density. Under both notions of curvature we classify the constant curvature manifolds. We also prove generalizations of the theorems of Cartan–Hadamard, Synge,
W. Wylie
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Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
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Nasal and temporal curvatures of lamina CRIBROSA in myopic eyes
Scientific Reports, 2022 Little is known about the myopic characteristics of lamina cribrosa (LC) curvature. As such, we investigated nasal and temporal LC curvatures in myopia.
Sooyeon Choe +6 more
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Remarks on Sectional Curvature of an Indefinite Metric [PDF]
Proceedings of the American Mathematical Society, 1983 The properties of sectional curvature for an indefinite metric are further studied following the works of R. S. Kulkarni, L. Graves and the author, S. G. Harris, and M. Dajczer and the author.
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
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ON SHRINKING GRADIENT RICCI SOLITONS WITH NONNEGATIVE SECTIONAL CURVATURE [PDF]
, 2013 In this paper, we prove some rigidity theorems for shrinking gradient Ricci solitons with nonnegative sectional curvature.
Mingliang Cai
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
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Sectional curvatures distribution of complexity geometry
Journal of High Energy Physics, 2022 Abstract In the geometric approach to defining complexity, operator complexity is defined as the distance in the operator space. In this paper, based on the analogy with the circuit complexity, the operator size is adopted as the metric of the operator space where the path length is the complexity.
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