Results 81 to 90 of about 129,831 (277)
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Advanced Engineering Materials, EarlyView., 2023 A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
CR-submanifolds of a locally conformal Kaehler space form
International Journal of Mathematics and Mathematical Sciences, 1994 (Bejancu [1,2]) The purpose of this paper is to continue the study of CR-submanifolds, and in particular of those of a locally conformal Kaehler space form (Matsumoto [3]).
M. Hasan Shahid
doaj +1 more source
A special deformation of the metric with no negative sectional curvature of a Riemannian space [PDF]
, 1969 Grigorios Tsagas
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
On isometric immersions in Euclidean space of manifolds with non-negative sectional curvatures [PDF]
, 1965 Philip Hartman
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Lorentzian Beltrami-Euler formula and generalized Lorentzian Lamarle formila in R_1^n
Le Matematiche, 2009 In this paper, the sectional curvature of non-degenerate tangent sections of time-like ruled surface with the central ruled surface in n-dimensional Minkowski space, R_1^n is studied. The relationship between normal sectional curvature and the principal
Soley Ersoy, Murat Tosun
doaj
On totally umbilical CR-submanifolds of a Kaehler manifold
International Journal of Mathematics and Mathematical Sciences, 1993 Let M be a compact 3-dimensional totally umbilical CR-submanifold of a Kaehler manifold of positive holomorphic sectional curvature. We prove that if the length of the mean curvature vector of M does not vanish, then M is either diffeomorphic to S3 or ...
M. A. Bashir
doaj +1 more source