Results 51 to 60 of about 5,783 (206)

YidC and SecYEG form a heterotetrameric protein translocation channel

Scientific Reports, 2017
The heterotrimeric SecYEG complex cooperates with YidC to facilitate membrane protein insertion by an unknown mechanism. Here we show that YidC contacts the interior of the SecY channel resulting in a ligand-activated and voltage-dependent complex with ...
Ilie Sachelaru, Lukas Winter, Denis G. Knyazev, Mirjam Zimmermann, Andreas Vogt, Roland Kuttner, Nicole Ollinger, Christine Siligan, Peter Pohl, Hans-Georg Koch   +9 more
doaj   +1 more source

Room‐temperature crystal structure of a metal‐dependent W‐formate dehydrogenase by serial synchrotron crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1072-1081, September 2026.
We report a room‐temperature serial synchrotron X‐ray crystallographic structural analysis of Nitratidesulfovibrio vulgaris formate dehydrogenase AB, an enzyme that reduces CO2 to formate.Metal‐dependent formate dehydrogenases (Fdhs) are a promising research target in efforts to mitigate climate change by developing active, efficient, selective and ...
Guilherme Vilela-Alves, Guilherme Martins, David von Stetten, Pedram Mehrabi, Inês A. C. Pereira, Maria João Romão, Arwen R. Pearson, Cristiano Mota   +7 more
wiley   +1 more source

A Single Amino Acid Substitution in SecY Stabilizes the Interaction with SecA [PDF]

, 1999
The SecYEG complex constitutes a protein conducting channel across the bacterial cytoplasmic membrane. It binds the peripheral ATPase SecA to form the translocase.
van der Does, C., Driessen, A.J.M., Kaufmann, A, Does, Chris van der,, Manting, E.H, Manting, Erik H.,, Driessen, Arnold J.M.,, Kaufmann, Andreas,   +7 more
core   +2 more sources

In vivo cross-linking of the SecA and SecY subunits of the Escherichia coli preprotein translocase [PDF]

, 1997
Precursor protein translocation across the Escherichia coli inner membrane is mediated by the translocase, which is composed of a heterotrimeric integral membrane protein complex with SecY, SecE, and SecG as subunits and peripherally bound SecA.
Driessen, Arnold J.M., Manting, Erik H., Does, Chris van der   +2 more
core   +9 more sources

Electrostatics inside the SecY Translocon [PDF]

Biophysical Journal, 2015
SecY constitutes the core of the highly conserved SecYEG translocon complex that governs the translocation or integration of proteins across or into cytoplasmic membranes. Besides its role of guiding nascent membrane protein chains into the lipid bilayer, it also plays an important role in determining transmembrane topology via the so-called positive ...
Capponi, Sara, White, Stephen H
openaire   +2 more sources

Scientific opinion on the assessment of dietary intake of selenium in the adult population of the Republic of Croatia

Food Risk Assess Europe, Volume 4, Issue 3, July 2026.
Summary Selenium is an essential trace element involved in numerous physiological processes, including antioxidant defence, regulation of thyroid hormone metabolism, immune function, and reproductive health. The aim of this scientific opinion was to assess dietary selenium intake in the adult population of the Republic of Croatia and to evaluate ...
Ivona Sučić, Martina Jurković, Zdenko Lončarić, Ines Banjari, Jasenka Gajdoš Kljusurić, Martina Pavlić, Dražen Knežević   +6 more
wiley   +1 more source

In Silico Discovery of Novel Drug and Vaccine Targets in Chlamydia abortus Through Subtractive Genomics

The Iraqi Journal of Veterinary Medicine
Chlamydia abortus is a Gram-negative bacterium that causes chlamydiosis, a zoonotic disease leading to abortions and stillbirths in livestock and posing significant public health risks.
Zainab Oun Ali, Sura Al-Asadi, Batool Hazim Abdul Wahhab, Jamila Rampurawala   +3 more
doaj   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY

, 2019
During their biosynthesis, many proteins pass through the membrane via a hydrophilic channel formed by the heterotrimeric Sec61/SecY complex. Whether this channel forms at the interface of multiple copies of Sec61/SecY or is intrinsic to a monomeric ...
Cannon, Kurt S., Rapoport, Tom A., Shibata, Yoko, Or, Eran, Clemons, William M.   +4 more
core   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source