Results 121 to 130 of about 399,623 (388)

To Sedate or Not to Sedate? [PDF]

open access: yesJournal of Pain and Symptom Management, 2007
Gilbert B. Zulian, Sophie Pautex
openaire   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

A Checklist to Document Sedation Competency

open access: yesMedEdPORTAL, 2008
Introduction Pediatric procedural sedation is an area of increasing focus. In practice, many pediatricians may be called upon to provide sedation for children in diverse settings.
Karen Judy, Kathleen Webster
doaj   +1 more source

Patient anxiety and modern elective surgery: a literature review [PDF]

open access: yes, 2003
Medical advances have led to a considerable rise in the level of elective surgery undertaken as day-case surgery and with minimal hospital stay. However, amid such advances, preoperative psychological care has remained relatively static.
Mitchell, MJ
core   +1 more source

Anxiety in Children Undergoing VCUG: Sedation or No Sedation? [PDF]

open access: yesAdvances in Urology, 2008
Background. Voiding cystourethrograms are distressing for children and parents. Nonpharmacological methods reduce distress. Pharmacological interventions for VCUG focus on sedation as well as analgesia, anxiolysis, and amnesia. Sedation has cost, time, and safety issues. Which agents and route should we use? Are we sure that sedation does not influence
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Risk factors for chloral hydrate sedation failure in pediatric patients: a retrospective analysis [PDF]

open access: yesKorean Journal of Anesthesiology
Background This study aimed to investigate the risk factors for chloral hydrate sedation failure and complications in a tertiary children’s hospital in South Korea.
Young-Eun Jang   +7 more
doaj   +1 more source

Evolving targets for sedation during mechanical ventilation.

open access: yesCurrent Opinion in Critical Care, 2019
PURPOSES OF REVIEW Critically ill patients frequently require mechanical ventilation as part of their care. Administration of analgesia and sedation to ensure patient comfort and facilitate mechanical ventilation must be balanced against the known ...
S. Pearson, B. Patel
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Room for Quality Improvement in Endoscopist-Directed Sedation: Results from the First Nationwide Survey in Korea

open access: yesGut and Liver, 2016
Background/AimsThis study sought to characterize the current sedation practices of Korean endoscopists in real-world settings.Methods : All active members of the Korean Society of Gastrointestinal Endoscopy were invited to complete an anonymous 35-item ...
doaj   +1 more source

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