Results 61 to 70 of about 388,946 (338)

Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy [PDF]

, 2018
Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease.
A Klang, A Pakozdy, A Pakozdy, A Pakozdy, A Pellegrini, AD Quesnel, Akos Pakozdy, AM Wahle, AS Sawchuk, C Bertolani, CR Hooijmans, CW Dewey, D Hasegawa, D Hughes, D Moher, D Schwartz-Porsche, D Schwartz-Porsche, DB Roye, DE Cuff, DL Zoran, DM Boothe, DM Brewer, G Zaccara, G Zaccara, GE Solomon, GH Guyatt, H Volk, Holger A. Volk, JA Berlin, JA Wada, JAD Gasper, JM Ducote, KE Finnerty, KS Bailey, KS Bailey, LR Barnard, M Charalambous, M Charalambous, M Lowrie, M Podell, MA Cautela, MA Holmes, Marios Charalambous, MB Carnes, MJ Baho, NM van Gelder, O Engel, P Boydell, PN Papanikolaou, R Chou, S Cizinauskas, S Schriefl, S Wagner, SA Center, SD Ross, SF Bhatti, SM Cochrane, SM Cochrane, Sofie F. M. Bhatti   +58 more
core   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Orofacial Migraine and Neurovascular Orofacial Pain: Response to Treatment—A Pilot Study

Biomedicines
Introduction: The International Classification of Orofacial Pain (ICOP) recognizes orofacial migraine (OFM) and neurovascular orofacial pain (NVOP) as migraine-related entities affecting the facial and oral regions.
Rafael Benoliel, Yair Sharav, Shimrit Heiliczer, Yaron Haviv   +3 more
doaj   +1 more source

Procedural Sedation and Analgesia in Children: Perspectives from Paediatric Emergency Physicians

Proceedings of Singapore Healthcare, 2010
Procedural sedation and analgesia in children is now widely practised in many emergency departments internationally. In this article, we address the general principles, indications, guidelines, medications, adverse events and future research in ...
Lai Peng Tham MBBS, MMed (Paediatrics), Khai Pin Lee M.Med (Paediatrics) MRCPCH   +1 more
doaj   +1 more source

Research progress of the application of conscious sedation in dental treatment for elderly patients [PDF]

Kouqiang yixue
The proportion of elderly patients has been increasing in recent years, as has the risk of cardiovascular accidents caused by tension, pain, and other stimuli in dental treatment.
LIU Bing, ZHANG Hui
doaj   +1 more source

Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS).

Journal of the American Medical Association (JAMA), 2003
CONTEXT Goal-directed delivery of sedative and analgesic medications is recommended as standard care in intensive care units (ICUs) because of the impact these medications have on ventilator weaning and ICU length of stay, but few of the available ...
E. Ely, B. Truman, A. Shintani, J. W. Thomason, Arthur P. Wheeler, S. Gordon, J. Francis, T. Speroff, S. Gautam, R. Margolin, C. Sessler, R. Dittus, Gordon R. Bernard   +12 more
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Alteration of coupling between brain and heart induced by sedation with propofol and midazolam.

PLoS ONE, 2019
For a comprehensive understanding of the nervous system, several previous studies have examined the network connections between the brain and the heart in diverse conditions. In this study, we identified coupling between the brain and the heart along the
Dong-Ok Won, Bo-Ram Lee, Kwang-Suk Seo, Hyun Jeong Kim, Seong-Whan Lee   +4 more
doaj   +1 more source

Use of volatile agents for sedation in the intensive care unit: A national survey in France.

PLoS ONE, 2021
BackgroundCurrent intensive care unit (ICU) sedation guidelines recommend strategies using non-benzodiazepine sedatives. This survey was undertaken to explore inhaled ICU sedation practice in France.MethodsIn this national survey, medical directors of ...
Raiko Blondonnet, Audrey Quinson, Céline Lambert, Jules Audard, Thomas Godet, Ruoyang Zhai, Bruno Pereira, Emmanuel Futier, Jean-Etienne Bazin, Jean-Michel Constantin, Matthieu Jabaudon   +10 more
doaj   +1 more source

A Comparison of Moderate Oral Sedation Drug Regimens for Pediatric Dental Treatment: A Pilot Study [PDF]

, 2017
Purpose: Compare moderate oral sedation of pediatric patients using Hydroxyzine and Meperidine with either Diazepam or Midazolam in management of pediatric dental patients. Methods: Randomized, double-blind, crossover pilot study of patients 3 to 7 years
Parikh, Ojas A
core   +1 more source