Results 81 to 90 of about 1,621,802 (299)

Investigation the Joint Probabilistic Behavior of River Flow Discharge-Suspended Sediment Load in Nazlochai Basin, Urmia [PDF]

Water Harvesting Research
Accurately determining the relationship between river flow discharge and suspended sediment load in watersheds is challenging due to the influence of natural and human-induced variables on river estimations.
Soraya Tavasoli, Keivan Khalili, Mohammad Nazeri Tahroudi   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interactions between coarse sediment transfer, channel change, river engineering and flood risk in an upland gravel-bed river [PDF]

, 2008
Coarse sediment transfer in upland gravel-bed river systems is often neglected in the design and operation of river management schemes. Yet, it is increasingly attributed to problems within upland environments including bank erosion and enhanced flood ...
Waterhouse, Emma Kate
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The erodibility of fine sediment deposits in lowland chalk streams [PDF]

, 2011
PhDLowland chalk streams in the UK are experiencing increased deposition of fine sediment due to changes in land-use practices, channel modifications, and groundwater abstraction.
Grabowski, Robert Carl
core   +4 more sources

Contribution of River Mouth Reach to Sediment Load of the Yangtze River

Advances in Meteorology, 2015
This paper examined the sediment gain and loss in the river mouth reach of the Yangtze River by considering sediment load from the local tributaries, erosion/accretion of the river course, impacts of sand mining, and water extraction.
C. Wang, S. B. Dai, L. S. Ran, L. Jiang, W. T. Li   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Recent changes in runoff and sediment regimes and future projections in the Yellow River basin

Shui kexue jinzhan, 2013
The runoff and sediment regimes in the Yellow River Basin have been undergone significantly changes in recent years. This study analyzes the changes in runoff and sediment regimes during the period 1997—2006 using the combined approach of hydrological ...
YAO Wenyi, RAN Dachuan, CHEN Jiangnan
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source