FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Suspended sediment load prediction modelling based on artificial intelligence methods: The tropical region as a case study. [PDF]
Heliyon, 2023 Allawi MF +4 more
europepmc +1 more source
Modeling sediment yields in Italian catchments. [PDF]
, 2005 Sediment yield observations, derived from 40 long-term sedimentation records in Italian reservoirs, were used to calibrate and validate the spatially distributed sediment delivery model WaTEM/SEDEM using the best data available at national scale.
van Rompaey, Anton +3 more
core +1 more source
Shuitu baochi yanjiu[Objective]The aims of this study are to explore the change characteristics and driving factors of runoff and sediment load in the Weihe River Basin, and to provide scientific basis for water resource management and ecological environment construction in
Hu Zuolong +3 more
doaj
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Response of Soil Detachment Rate to Sediment Load and Model Examination: A Key Process Simulation of Rill Erosion on Steep Loessial Hillslopes. [PDF]
Int J Environ Res Public Health, 2023 Shen N, Wang Z, Zhang F, Zhou C.
europepmc +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Suspended sediment load prediction using long short-term memory neural network. [PDF]
Sci Rep, 2021 AlDahoul N +6 more
europepmc +1 more source
Analysis of the Sediment Trapping by Reservoirs in the Upper Yangtze River
工程科学与技术, 2015 :Reservoirs play a pivotal role in trapping sediments and reducing sediment load into the downstream reach. The construction of reservoirs in the upper Yangtze River had reached its peak since 2003 when the Three Gorges Reservoir was putted into ...
DUAN Yanchong, LI Danxun, WANG Xingkui
doaj