Results 61 to 70 of about 91,077 (265)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The transportation for cohesive bank‐collapsed materials in a straight channel with the prospect of climate change

Engineering Reports
The transportation of bank‐collapsed materials is a key issue among river evolution processes. In this study, a series of flume experiments were conducted to monitor riverbank collapse processes and to explore the regularity of transportation for ...
Haifei Liu, Guosheng Duan, Li Cheng
doaj   +1 more source

Effects of River-Ice Breakup on Sediment Transport and Implications to Stream Environments: A Review

, 2021
During the breakup of river ice covers, a greater potential for erosion occurs due to rising discharge and moving ice and the highly dynamic waves that form upon ice-jam release.
Spyros Beltaos, Brian C. Burrell
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Modeling the Impacts of Land Reclamation on Sediment Dynamics in a Semi-Enclosed Bay

Journal of Marine Science and Engineering
Semi-enclosed bays are significantly influenced by the interactions between land and sea, as well as human activities. One notable human activity, land reclamation, impacts water exchange within these bays.
Yi Zhong, Jun Du, Yongzhi Wang, Ping Li, Guoqiang Xu, Hongbin Miu, Peiyu Zhang, Shenghui Jiang, Wei Gao   +8 more
doaj   +1 more source

Assessment of hydrology, sediment and particulate organic carbon yield in a large agricultural catchment using the SWAT model [PDF]

, 2011
The Soil and Water Assessment Tool (SWAT, 2005) was used to simulate discharge and sediment transport at daily time steps within the intensively farmed Save catchment in south-west France (1110 km2).
Simeoni-Sauvage, Sabine, Oeurng, Chantha, Sánchez-Pérez, J.M., Chantha Oeurng, Sanchez-Pérez, José Miguel, Sabine Sauvage, José-Miguel Sánchez-Pérez   +6 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Numerical Simulation of Flow and Suspended Sediment Transport in the Distributary Channel Networks

Journal of Applied Mathematics, 2014
Flow and suspended sediment transport in distributary channel networks play an important role in the evolution of deltas and estuaries, as well as the coastal environment.
Wei Zhang, Qiong Jia, Xiaowen Chen
doaj   +1 more source