Results 81 to 90 of about 2,492,137 (249)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2019 In Taiwan, the steep landscape and highly vulnerable geology make it difficult to predict soil erosion and sediment transportation via variable transport conditions.
Chih-Mei Lu, Li-Chi Chiang
core +1 more source
RiverBedload studies at the particle scale may help grasp the essence of the problem. Existing studies suffer from short filming durations, limited data volume, and a narrow range of sediment transport intensity variations.
Chunjing Liu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dynamics of fluvial fine sediment transfer in the River Esk, North Yorkshire, UK [PDF]
, 2006 A full understanding of the complexities of fluvial suspended sediment dynamics requires a holistic approach. The study presented here addresses fine sediment transfer in the River Esk catchment, which is suffering from the adverse effects of increased ...
Mills, Carolyn
core
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Shui kexue jinzhan, 2015 Based on the basic sediment transport equation that reflects the characteristics of "more input,more output"for sediment-laden flow rivers,a general sediment transport expression was developed,which can take into account the effects of upstream sediment ...
WU Baosheng +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Effect of Change in Precipitation-Land Use on Runoff and Sediment Transport in Semi-Arid Areas
Shuitu baochi yanjiu, 2020 In order to further study the internal mechanism and relationship of effects of annual precipitation and land use patterns on annual runoff and sediment transport, Anding District, Dingxi City, Gansu Province was selected as the research area, and Mann ...
JIN Feng +5 more
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source