Results 81 to 90 of about 91,077 (265)
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
RiverBedload studies at the particle scale may help grasp the essence of the problem. Existing studies suffer from short filming durations, limited data volume, and a narrow range of sediment transport intensity variations.
Chunjing Liu +6 more
doaj +1 more source
The Sediment Dynamics of Ahuriri Estuary, Napier, New Zealand
, 2009 Ahuriri Estuary is a shallow, microtidal estuary located in Hawke's Bay, New Zealand. Sediment transport pathways and areas of potential erosion and accretion of Ahuriri Estuary are identified to enhance the understanding of the fate of contaminants ...
Eyre, Tracey Michelle
core
Cadmium transport in sediments by tubificid bioturbation: An assessment of model complexity [PDF]
, 2006 Biogeochemistry of metals in aquatic sediments is strongly influenced by bioturbation. To determine the effects of biological transport on cadmium distribution in freshwater sediments, a bioturbation model is explored that describes the conveyor-belt ...
Boudou, A. +11 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Modelling subglacial fluvial sediment transport with a graph-based model, Graphical Subglacial Sediment Transport (GraphSSeT) [PDF]
The CryosphereA quantitative understanding of how sediment discharge from subglacial fluvial systems varies in response to glaciohydrological conditions is essential for understanding marine systems around Greenland and Antarctica and for interpreting sedimentary ...
A. R. A. Aitken +6 more
doaj +1 more source
, 2008 Nearshore sand transport patterns along the tideless, embayed Pirita beach, Tallinn, Estonia, have been investigated utilizing high-resolution modelling of wave processes combined with bathymetric surveys and sediment textural analyses of the nearshore ...
Kask, Andres +3 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Applied SciencesThe sediment yield resulting from storm erosion has become a focal point of research and a significant area of interest in the upper reaches of the Yangtze River amid changing environmental conditions. The issue of numerous types of erosivity factors (R)
Wei Miao +6 more
doaj +1 more source