Results 91 to 100 of about 201,517 (307)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Quantifying slope-channel coupling in an active gully and fan complex at Tarndale, Waipaoa catchment, New Zealand [PDF]

, 2010
Two RIEGL LMS‐Z420i scanner surveys (November 2007 and November 2008) of the Tarndale Gully complex and its associated fan were used to generate a digital elevation model (DEM) of difference in order to quantify gully‐fan‐channel connectivity.
Dean, Josh F, Fuller, Ian C, Marden, Mike, Massey, Chris, Phillips, Emma   +4 more
core  

Modeling nitrogen loadings from agricultural soils in southwest China with modified DNDC [PDF]

, 2011
Degradation of water quality has been widely observed in China, and loadings of nitrogen (N) and other nutrients from agricultural systems play a key role in the water contamination.
Deng, Jia, Li, Changsheng, Tang, Jialiang, Wang, Tao, Zheng, Xunhua, Zhou, Zaixing, Zhu, Bo   +6 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Transformation of Sediment Into Rock : Insights From IODP Site U1352, Canterbury Basin, New Zealand [PDF]

, 2017
ACKNOWLEDGMENTS We thank the crew of the RV JOIDES Resolution for professional seamanship, excellent drilling, and the scientific support on board. GHB and SCG thank the Australia–New Zealand IODP Consortium (ANZIC), and KMM thanks the Consortium for ...
Browne, Greg H., Carson, David, Dinarès-Turell, Jaume, George, Simon C., IODP Expedition 317 Scientific Party, Jaeger, John M., Kemp, David B., Marsaglia, Kathleen M., Richaud, Mathieu   +8 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Distributed sediment yield modelling: Importance of initial sediment conditions

Environmental Modelling & Software, 2014
The importance of initial sediment conditions on model calibration and validation is analysed. A sediment model was calibrated and validated under three different initial sediment conditions: (0) no sediment availability, (1) calibration of the initial sediment condition and (2) using a warm-up simulation.
Gianbattista Bussi, Félix Francés, Juan José Montoya, Pierre Y. Julien   +3 more
openaire   +4 more sources

Discordance between cosmogenic nuclide concentrations in amalgamated sands and individual fluvial pebbles in an arid zone catchment [PDF]

, 2014
Based on cosmogenic 10Be and 26Al analyses in 15 individual detrital quartz pebbles (16–21 mm) and cosmogenic 10Be in amalgamated medium sand (0.25–0.50 mm), all collected from the outlet of the upper Gaub River catchment in Namibia, quartz pebbles yield
Bishop, Paul, Codilean, Alexandru T., Fabel, Derek, Fenton, Cassandra R., Xu, Sheng   +4 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Changes in sediment connectivity and its impact on sediment transport in a typical watershed of Southern Jiangxi Province, China

Ecological Indicators
Sediment connectivity is a crucial factor in determining the mode, efficiency, and scale of sediment transport. However, changes in sediment connectivity and their impact on sediment transport in southern Jiangxi Province, China, remain unclear ...
Fei Sheng, Tingxin Yi, Yanyan Wang, Haijin Zheng, Shiyu Liu, Xiaofei Nie, Longsong Hu, Haifeng Li   +7 more
doaj   +1 more source