Results 111 to 120 of about 636,102 (287)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
How do mangrove forests induce sedimentation?
Revista de Biología Tropical, 2003 The mangrove forests play a significant role as sediment traps. They reduce tidal flows and induce sedimentation of soil particles at low tide. However, there are no such processes taking place in the non-mangrove areas.
K. Kathiresan
doaj +2 more sources
Competition between Chemical and Gravity Forces in Binary Alloys
High Temperature Materials and Processes, 2018 We present the first experimental results of the growth of Cu6Sn5 and Cu3Sn under an external force field – during the sedimentation process. The results are compared with the proposed model under the combined influence of the Kirkendall effect ...
Wierzba Bartek +2 more
doaj +1 more source
The Impact of a Check Dam on Groundwater Recharge and Sedimentation in an Ephemeral Stream [PDF]
, 2017 Hakan Djuma +4 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli +4 more
wiley +1 more source
Concentration and sedimentation rates of blood from the splenic artery and vein [PDF]
, 1938 J. G. Stephens
openalex +1 more source
Soil Formation, Subaerial Sedimentation Processes and Ancient Cultures during MIS 2 and the Deglaciation Phase MIS 1 in the Baikal–Yenisei Siberia (Russia) [PDF]
, 2021 G. A. Vorobieva +6 more
openalex +1 more source